Abstract
Objective - To determine whether preoperative left ventricular ejection fraction (LVEF) is related to the degree of myocardial oxidative stress during bypass surgery in man. Design - Observation study. Setting - Tertiary care centre. Patients and interventions -31 patients (LVEF range was 20% to 68%) undergoing elective coronary bypass surgery with blood cardioplegic reperfusion were studied. Arterial and coronary sinus blood was collected before aortic cross clamping (T1) and at 0 (T1), 15 (T2), and 30 (T3) minutes after unclamping. Transmural left ventricular biopsies were also obtained from 15 patients at T0 and at T1. Main outcome measures - Glutathione and adenine nucleotides were measured in myocardial biopsies, while coronary sinus-artery differences for glutathione, nucleotides, and products of lipids peroxidation were calculated from blood specimens. Creatine kinase (myocardial band; CK-MB) was measured in plasma at four and 12 hours after operation. Results - Myocardial glutathione and adenine nucleotides were correlated (p
| Original language | English |
|---|---|
| Pages (from-to) | 242-247 |
| Number of pages | 6 |
| Journal | Heart |
| Volume | 79 |
| Issue number | 3 |
| Publication status | Published - 1998 |
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Keywords
- Aortocoronary bypass
- Glutathione
- Lipid peroxidation
- Oxidative stress
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Relation between left ventricular function and oxidative stress in patients undergoing bypass surgery. / De Vecchi, E.; Pala, M. G.; Di Credico, G.; Agape, V.; Paolini, G.; Bonini, P. A.; Grossi, A.; Paroni, R.
In: Heart, Vol. 79, No. 3, 1998, p. 242-247.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Relation between left ventricular function and oxidative stress in patients undergoing bypass surgery
AU - De Vecchi, E.
AU - Pala, M. G.
AU - Di Credico, G.
AU - Agape, V.
AU - Paolini, G.
AU - Bonini, P. A.
AU - Grossi, A.
AU - Paroni, R.
PY - 1998
Y1 - 1998
N2 - Objective - To determine whether preoperative left ventricular ejection fraction (LVEF) is related to the degree of myocardial oxidative stress during bypass surgery in man. Design - Observation study. Setting - Tertiary care centre. Patients and interventions -31 patients (LVEF range was 20% to 68%) undergoing elective coronary bypass surgery with blood cardioplegic reperfusion were studied. Arterial and coronary sinus blood was collected before aortic cross clamping (T1) and at 0 (T1), 15 (T2), and 30 (T3) minutes after unclamping. Transmural left ventricular biopsies were also obtained from 15 patients at T0 and at T1. Main outcome measures - Glutathione and adenine nucleotides were measured in myocardial biopsies, while coronary sinus-artery differences for glutathione, nucleotides, and products of lipids peroxidation were calculated from blood specimens. Creatine kinase (myocardial band; CK-MB) was measured in plasma at four and 12 hours after operation. Results - Myocardial glutathione and adenine nucleotides were correlated (p
AB - Objective - To determine whether preoperative left ventricular ejection fraction (LVEF) is related to the degree of myocardial oxidative stress during bypass surgery in man. Design - Observation study. Setting - Tertiary care centre. Patients and interventions -31 patients (LVEF range was 20% to 68%) undergoing elective coronary bypass surgery with blood cardioplegic reperfusion were studied. Arterial and coronary sinus blood was collected before aortic cross clamping (T1) and at 0 (T1), 15 (T2), and 30 (T3) minutes after unclamping. Transmural left ventricular biopsies were also obtained from 15 patients at T0 and at T1. Main outcome measures - Glutathione and adenine nucleotides were measured in myocardial biopsies, while coronary sinus-artery differences for glutathione, nucleotides, and products of lipids peroxidation were calculated from blood specimens. Creatine kinase (myocardial band; CK-MB) was measured in plasma at four and 12 hours after operation. Results - Myocardial glutathione and adenine nucleotides were correlated (p
KW - Aortocoronary bypass
KW - Glutathione
KW - Lipid peroxidation
KW - Oxidative stress
UR - http://www.scopus.com/inward/record.url?scp=0031945773&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031945773&partnerID=8YFLogxK
M3 - Article
C2 - 9602656
AN - SCOPUS:0031945773
VL - 79
SP - 242
EP - 247
JO - Heart
JF - Heart
SN - 1355-6037
IS - 3
ER -