Relation between left ventricular function and oxidative stress in patients undergoing bypass surgery

E. De Vecchi; M. G. Pala; G. Di Credico; V. Agape; G. Paolini; P. A. Bonini; A. Grossi; R. Paroni

Relation between left ventricular function and oxidative stress in patients undergoing bypass surgery

E. De Vecchi, M. G. Pala, G. Di Credico, V. Agape, G. Paolini, P. A. Bonini, A. Grossi, R. Paroni

IRCCS Istituto Ortopedico Galeazzi

Research output: Contribution to journal › Article › peer-review

Abstract

Objective - To determine whether preoperative left ventricular ejection fraction (LVEF) is related to the degree of myocardial oxidative stress during bypass surgery in man. Design - Observation study. Setting - Tertiary care centre. Patients and interventions -31 patients (LVEF range was 20% to 68%) undergoing elective coronary bypass surgery with blood cardioplegic reperfusion were studied. Arterial and coronary sinus blood was collected before aortic cross clamping (T1) and at 0 (T1), 15 (T2), and 30 (T3) minutes after unclamping. Transmural left ventricular biopsies were also obtained from 15 patients at T0 and at T1. Main outcome measures - Glutathione and adenine nucleotides were measured in myocardial biopsies, while coronary sinus-artery differences for glutathione, nucleotides, and products of lipids peroxidation were calculated from blood specimens. Creatine kinase (myocardial band; CK-MB) was measured in plasma at four and 12 hours after operation. Results - Myocardial glutathione and adenine nucleotides were correlated (p

Original language	English
Pages (from-to)	242-247
Number of pages	6
Journal	Heart
Volume	79
Issue number	3
Publication status	Published - 1998

Keywords

Aortocoronary bypass
Glutathione
Lipid peroxidation
Oxidative stress

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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title = "Relation between left ventricular function and oxidative stress in patients undergoing bypass surgery",

abstract = "Objective - To determine whether preoperative left ventricular ejection fraction (LVEF) is related to the degree of myocardial oxidative stress during bypass surgery in man. Design - Observation study. Setting - Tertiary care centre. Patients and interventions -31 patients (LVEF range was 20% to 68%) undergoing elective coronary bypass surgery with blood cardioplegic reperfusion were studied. Arterial and coronary sinus blood was collected before aortic cross clamping (T1) and at 0 (T1), 15 (T2), and 30 (T3) minutes after unclamping. Transmural left ventricular biopsies were also obtained from 15 patients at T0 and at T1. Main outcome measures - Glutathione and adenine nucleotides were measured in myocardial biopsies, while coronary sinus-artery differences for glutathione, nucleotides, and products of lipids peroxidation were calculated from blood specimens. Creatine kinase (myocardial band; CK-MB) was measured in plasma at four and 12 hours after operation. Results - Myocardial glutathione and adenine nucleotides were correlated (p",

keywords = "Aortocoronary bypass, Glutathione, Lipid peroxidation, Oxidative stress",

author = "{De Vecchi}, E. and Pala, {M. G.} and {Di Credico}, G. and V. Agape and G. Paolini and Bonini, {P. A.} and A. Grossi and R. Paroni",

year = "1998",

language = "English",

volume = "79",

pages = "242--247",

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T1 - Relation between left ventricular function and oxidative stress in patients undergoing bypass surgery

AU - De Vecchi, E.

AU - Pala, M. G.

AU - Di Credico, G.

AU - Agape, V.

AU - Paolini, G.

AU - Bonini, P. A.

AU - Grossi, A.

AU - Paroni, R.

PY - 1998

Y1 - 1998

N2 - Objective - To determine whether preoperative left ventricular ejection fraction (LVEF) is related to the degree of myocardial oxidative stress during bypass surgery in man. Design - Observation study. Setting - Tertiary care centre. Patients and interventions -31 patients (LVEF range was 20% to 68%) undergoing elective coronary bypass surgery with blood cardioplegic reperfusion were studied. Arterial and coronary sinus blood was collected before aortic cross clamping (T1) and at 0 (T1), 15 (T2), and 30 (T3) minutes after unclamping. Transmural left ventricular biopsies were also obtained from 15 patients at T0 and at T1. Main outcome measures - Glutathione and adenine nucleotides were measured in myocardial biopsies, while coronary sinus-artery differences for glutathione, nucleotides, and products of lipids peroxidation were calculated from blood specimens. Creatine kinase (myocardial band; CK-MB) was measured in plasma at four and 12 hours after operation. Results - Myocardial glutathione and adenine nucleotides were correlated (p

AB - Objective - To determine whether preoperative left ventricular ejection fraction (LVEF) is related to the degree of myocardial oxidative stress during bypass surgery in man. Design - Observation study. Setting - Tertiary care centre. Patients and interventions -31 patients (LVEF range was 20% to 68%) undergoing elective coronary bypass surgery with blood cardioplegic reperfusion were studied. Arterial and coronary sinus blood was collected before aortic cross clamping (T1) and at 0 (T1), 15 (T2), and 30 (T3) minutes after unclamping. Transmural left ventricular biopsies were also obtained from 15 patients at T0 and at T1. Main outcome measures - Glutathione and adenine nucleotides were measured in myocardial biopsies, while coronary sinus-artery differences for glutathione, nucleotides, and products of lipids peroxidation were calculated from blood specimens. Creatine kinase (myocardial band; CK-MB) was measured in plasma at four and 12 hours after operation. Results - Myocardial glutathione and adenine nucleotides were correlated (p

KW - Aortocoronary bypass

KW - Glutathione

KW - Lipid peroxidation

KW - Oxidative stress

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M3 - Article

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JO - Heart

JF - Heart

SN - 1355-6037

IS - 3

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Relation between left ventricular function and oxidative stress in patients undergoing bypass surgery

Abstract

Keywords

ASJC Scopus subject areas

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