Relation between left ventricular function and oxidative stress in patients undergoing bypass surgery

E. De Vecchi, M. G. Pala, G. Di Credico, V. Agape, G. Paolini, P. A. Bonini, A. Grossi, R. Paroni

Research output: Contribution to journalArticle

Abstract

Objective - To determine whether preoperative left ventricular ejection fraction (LVEF) is related to the degree of myocardial oxidative stress during bypass surgery in man. Design - Observation study. Setting - Tertiary care centre. Patients and interventions -31 patients (LVEF range was 20% to 68%) undergoing elective coronary bypass surgery with blood cardioplegic reperfusion were studied. Arterial and coronary sinus blood was collected before aortic cross clamping (T1) and at 0 (T1), 15 (T2), and 30 (T3) minutes after unclamping. Transmural left ventricular biopsies were also obtained from 15 patients at T0 and at T1. Main outcome measures - Glutathione and adenine nucleotides were measured in myocardial biopsies, while coronary sinus-artery differences for glutathione, nucleotides, and products of lipids peroxidation were calculated from blood specimens. Creatine kinase (myocardial band; CK-MB) was measured in plasma at four and 12 hours after operation. Results - Myocardial glutathione and adenine nucleotides were correlated (p

Original languageEnglish
Pages (from-to)242-247
Number of pages6
JournalHeart
Volume79
Issue number3
Publication statusPublished - 1998

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Keywords

  • Aortocoronary bypass
  • Glutathione
  • Lipid peroxidation
  • Oxidative stress

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

De Vecchi, E., Pala, M. G., Di Credico, G., Agape, V., Paolini, G., Bonini, P. A., Grossi, A., & Paroni, R. (1998). Relation between left ventricular function and oxidative stress in patients undergoing bypass surgery. Heart, 79(3), 242-247.