Relation between myocardial blood flow and the severity of coronary- artery stenosis

N. G. Uren, J. A. Melin, B. De Bruyne, W. Wijns, T. Baudhuin, P. G. Camici

Research output: Contribution to journalArticlepeer-review


Background. We assessed the relation between the severity of stenosis in a coronary artery and the degree of impairment of myocardial blood flow. Studies in laboratory animals have shown that as the degree of coronary- artery stenosis increases, the maximal coronary flow measured after maximal vasodilatation progressively decreases, with a concomitant decrease in basal flow. However, this relation has not been carefully documented in humans through measurement of myocardial blood flow. Methods. We studied 35 patients with single-vessel coronary artery disease and normal left ventricular function and 21 age-matched controls. Regional myocardial blood flow in the area supplied by the stenosed artery was measured by positron-emission tomography with oxygen-15-labeled water while the subject was at rest (basal flow) and during hyperemia induced by the intravenous administration of the vasodilator adenosine (140 μg per kilogram of body weight per minute) or dipyridamole (0.56 mg per kilogram). Results. The mean (±SD) basal myocardial blood flow was 1.14±0.42 ml per minute per gram of tissue in the patients and 1.13±0.26 ml per minute per gram in the controls; during hyperemia, myocardial flow was 2.10±1.16 and 3.37±1.25 ml per minute per gram (P

Original languageEnglish
Pages (from-to)1782-1788
Number of pages7
JournalNew England Journal of Medicine
Issue number25
Publication statusPublished - 1994

ASJC Scopus subject areas

  • Medicine(all)


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