Relation between platelet response to exercise and coronary angiographic findings in patients with effort angina

Gaetano Antonio Lanza, Alfonso Sestito, Sonia Iacovalla, Laura Morlacchi, Enrico Romagnoli, Giovanni Schiavoni, Filippo Crea, Attilio Masari, Felicita Andreotti

Research output: Contribution to journalArticlepeer-review

Abstract

Background - Platelet reactivity is increased by exercise in patients with obstructive coronary artery disease (CAD) but not in patients with syndrome X. In this study, we prospectively investigated whether the platelet response to exercise might help distinguish, among patients with angina, those with obstructive CAD from those with normal coronary arteries (NCAs). Methods and Results - Venous blood samples were collected before and 5 minutes after exercise from 194 consecutive patients with stable angina. Platelet reactivity was measured by the platelet function analyzer (PFA)-100 system as the time for flowing whole blood to occlude a collagen-adenosine diphosphate ring (closure time). Coronary angiography showed CAD in 163 patients (84%) and NCA in 31 patients (16%). Baseline closure time was shorter in NCA patients (78.0±16 versus 95.5±23 seconds, P

Original languageEnglish
Pages (from-to)1378-1382
Number of pages5
JournalCirculation
Volume107
Issue number10
DOIs
Publication statusPublished - Mar 18 2003

Keywords

  • Coronary disease
  • Platelets
  • Syndrome X
  • Tests

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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