TY - JOUR
T1 - Relation of childhood brain tumors to exposure of parents and children to tobacco smoke
T2 - The search international case-control study
AU - Filippini, Graziella
AU - Maisonneuve, Patrick
AU - McCredie, Margaret
AU - Peris-Bonet, Raphael
AU - Modan, Baruch
AU - Preston-Martin, Susan
AU - Mueller, Beth A.
AU - Holly, Elizabeth A.
AU - Cordier, Sylvaine
AU - Choi, N. W.
AU - Little, Julian
AU - Arslan, Annie
AU - Boyle, Peter
PY - 2002/7/10
Y1 - 2002/7/10
N2 - The etiology of childhood brain tumors (CBTs) remains unknown. Tobacco smoke contains several known carcinogens and can induce DNA adducts in human placenta and hemoglobin adducts in fetuses. We present the results of an international case-control study to evaluate the association between CBTs and exposure of parents and children to cigarette smoke. The study was undertaken as part of the SEARCH program of the IARC. Nine centers in 7 countries were involved. The studies mainly covered the 1980s and early 1990s. Cases (1,218, ages 0-19 years) were children newly diagnosed with a primary brain tumor; there were 2,223 population-based controls. Most mothers who agreed to participate were interviewed in person at home. Odds ratios (ORs) were calculated by unconditional logistic regression, adjusted for age, sex and center, for all types of CBT combined, 4 CBT histotypes, 5 age groups and each center. There was no association between the risk of brain tumors in the child and parental smoking prior to pregnancy, maternal smoking or regular exposure to others' cigarette smoke during pregnancy at home or at work, or passive smoking by the child during the first year of life. These results did not change considering the child's age at diagnosis, the histologic type of tumor or center.
AB - The etiology of childhood brain tumors (CBTs) remains unknown. Tobacco smoke contains several known carcinogens and can induce DNA adducts in human placenta and hemoglobin adducts in fetuses. We present the results of an international case-control study to evaluate the association between CBTs and exposure of parents and children to cigarette smoke. The study was undertaken as part of the SEARCH program of the IARC. Nine centers in 7 countries were involved. The studies mainly covered the 1980s and early 1990s. Cases (1,218, ages 0-19 years) were children newly diagnosed with a primary brain tumor; there were 2,223 population-based controls. Most mothers who agreed to participate were interviewed in person at home. Odds ratios (ORs) were calculated by unconditional logistic regression, adjusted for age, sex and center, for all types of CBT combined, 4 CBT histotypes, 5 age groups and each center. There was no association between the risk of brain tumors in the child and parental smoking prior to pregnancy, maternal smoking or regular exposure to others' cigarette smoke during pregnancy at home or at work, or passive smoking by the child during the first year of life. These results did not change considering the child's age at diagnosis, the histologic type of tumor or center.
KW - Brain tumors
KW - Case-control study
KW - Childhood cancer
KW - Passive smoking
KW - Pregnancy
KW - Smoking
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U2 - 10.1002/ijc.10465
DO - 10.1002/ijc.10465
M3 - Article
C2 - 12115571
AN - SCOPUS:0037054944
VL - 100
SP - 206
EP - 213
JO - International Journal of Cancer
JF - International Journal of Cancer
SN - 0020-7136
IS - 2
ER -