Abstract
The objectives of the present study were to determine the role of cognitive and mood disorders as determinants of health-related quality of life (HRQOL) in multiple sclerosis (MS), as well as to evaluate the validity of self-assessed HRQOL in cognitively impaired patients and the agreement between self-assessed and proxy-reported HRQOL. The study included 204 MS inpatients and outpatients seen between April and September 1997 at three participating centers. The MS quality of life 54 (MSQOL-54) was explained to the patients by a neurologist who also assisted them to complete the questionnaire. A proxy version of the MSQOL-54 was completed independently by each patient's designated proxy. The mean age of the patients was 43 years; the mean expanded disability status scale (EDSS) score was 4.5. Cognitively compromised patients had considerable difficulties in completing the questionnaire, and gave a high percentage of missing and inconsistent items. Depressive symptoms and age had the most important influence on patients' HRQOL. The level of agreement between self-assessed and proxy-reported HRQOL was moderate to substantial for most scales, with proxy informants rating patients as slightly more impaired. Although the patient should be the best informant concerning HRQOL, information from a proxy respondent may be preferable in patients with severe cognitive impairment.
| Original language | English |
|---|---|
| Journal | Italian Journal of Neurological Sciences |
| Volume | 19 |
| Issue number | 6 SUPPL. |
| Publication status | Published - 1998 |
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Keywords
- Multiple sclerosis
- Outcome measures
- Quality of life
ASJC Scopus subject areas
- Neuroscience(all)
- Clinical Neurology
- Psychiatry and Mental health
- Dermatology
Cite this
Relation of cognitive impairment and depression to quality of life in multiple sclerosis patients. / Solari, A.; Ghezzi, A.; Mendozzi, L.; Filippini, G.; Cifani, S.; Barbieri, E.; Baldini, S.; Salmaggi, A.; La Mantia, L.; Farinotti, M.; Caputo, D.; Mosconi, P.
In: Italian Journal of Neurological Sciences, Vol. 19, No. 6 SUPPL., 1998.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Relation of cognitive impairment and depression to quality of life in multiple sclerosis patients
AU - Solari, A.
AU - Ghezzi, A.
AU - Mendozzi, L.
AU - Filippini, G.
AU - Cifani, S.
AU - Barbieri, E.
AU - Baldini, S.
AU - Salmaggi, A.
AU - La Mantia, L.
AU - Farinotti, M.
AU - Caputo, D.
AU - Mosconi, P.
PY - 1998
Y1 - 1998
N2 - The objectives of the present study were to determine the role of cognitive and mood disorders as determinants of health-related quality of life (HRQOL) in multiple sclerosis (MS), as well as to evaluate the validity of self-assessed HRQOL in cognitively impaired patients and the agreement between self-assessed and proxy-reported HRQOL. The study included 204 MS inpatients and outpatients seen between April and September 1997 at three participating centers. The MS quality of life 54 (MSQOL-54) was explained to the patients by a neurologist who also assisted them to complete the questionnaire. A proxy version of the MSQOL-54 was completed independently by each patient's designated proxy. The mean age of the patients was 43 years; the mean expanded disability status scale (EDSS) score was 4.5. Cognitively compromised patients had considerable difficulties in completing the questionnaire, and gave a high percentage of missing and inconsistent items. Depressive symptoms and age had the most important influence on patients' HRQOL. The level of agreement between self-assessed and proxy-reported HRQOL was moderate to substantial for most scales, with proxy informants rating patients as slightly more impaired. Although the patient should be the best informant concerning HRQOL, information from a proxy respondent may be preferable in patients with severe cognitive impairment.
AB - The objectives of the present study were to determine the role of cognitive and mood disorders as determinants of health-related quality of life (HRQOL) in multiple sclerosis (MS), as well as to evaluate the validity of self-assessed HRQOL in cognitively impaired patients and the agreement between self-assessed and proxy-reported HRQOL. The study included 204 MS inpatients and outpatients seen between April and September 1997 at three participating centers. The MS quality of life 54 (MSQOL-54) was explained to the patients by a neurologist who also assisted them to complete the questionnaire. A proxy version of the MSQOL-54 was completed independently by each patient's designated proxy. The mean age of the patients was 43 years; the mean expanded disability status scale (EDSS) score was 4.5. Cognitively compromised patients had considerable difficulties in completing the questionnaire, and gave a high percentage of missing and inconsistent items. Depressive symptoms and age had the most important influence on patients' HRQOL. The level of agreement between self-assessed and proxy-reported HRQOL was moderate to substantial for most scales, with proxy informants rating patients as slightly more impaired. Although the patient should be the best informant concerning HRQOL, information from a proxy respondent may be preferable in patients with severe cognitive impairment.
KW - Multiple sclerosis
KW - Outcome measures
KW - Quality of life
UR - http://www.scopus.com/inward/record.url?scp=0001062774&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0001062774&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0001062774
VL - 19
JO - Italian Journal of Neurological Sciences
JF - Italian Journal of Neurological Sciences
SN - 0392-0461
IS - 6 SUPPL.
ER -