Relation of Heart Rate Variability to Serum Levels of C-Reactive Protein in Patients With Unstable Angina Pectoris

Gaetano A. Lanza, Gregory Angelo Sgueglia, Domenico Cianflone, Antonio G. Rebuzzi, Giulia Angeloni, Alfonso Sestito, Fabio Infusino, Filippo Crea, Attilio Maseri

Research output: Contribution to journalArticle

Abstract

Heart rate variability (HRV) and systemic markers of inflammation have prognostic value in patients with unstable angina pectoris (UAP). However, it is unknown whether any relation exists between HRV parameters and indexes of inflammation in this clinical context. We assessed HRV on 24-hour electrocardiographic Holter recordings, performed within 24 hours of admission, and measured C-reactive protein (CRP) serum levels by a high-sensitivity assay on admission, in 531 patients with UAP (65 ± 10 years of age; 347 men) who were enrolled in the prospective multicenter study Stratificazione Prognostica dell'Angina Instabile (SPAI). A significant inverse correlation was found between CRP levels and all HRV parameters, with the highest r coefficient shown with SD of all RR intervals (r = -0.23; p

Original languageEnglish
Pages (from-to)1702-1706
Number of pages5
JournalThe American Journal of Cardiology
Volume97
Issue number12
DOIs
Publication statusPublished - Jun 15 2006

Fingerprint

Unstable Angina
C-Reactive Protein
Heart Rate
Serum
Inflammation
Multicenter Studies
Prospective Studies

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Relation of Heart Rate Variability to Serum Levels of C-Reactive Protein in Patients With Unstable Angina Pectoris. / Lanza, Gaetano A.; Sgueglia, Gregory Angelo; Cianflone, Domenico; Rebuzzi, Antonio G.; Angeloni, Giulia; Sestito, Alfonso; Infusino, Fabio; Crea, Filippo; Maseri, Attilio.

In: The American Journal of Cardiology, Vol. 97, No. 12, 15.06.2006, p. 1702-1706.

Research output: Contribution to journalArticle

Lanza, Gaetano A. ; Sgueglia, Gregory Angelo ; Cianflone, Domenico ; Rebuzzi, Antonio G. ; Angeloni, Giulia ; Sestito, Alfonso ; Infusino, Fabio ; Crea, Filippo ; Maseri, Attilio. / Relation of Heart Rate Variability to Serum Levels of C-Reactive Protein in Patients With Unstable Angina Pectoris. In: The American Journal of Cardiology. 2006 ; Vol. 97, No. 12. pp. 1702-1706.
@article{ab7f31efd6ea44cfa5feebfd32e37c87,
title = "Relation of Heart Rate Variability to Serum Levels of C-Reactive Protein in Patients With Unstable Angina Pectoris",
abstract = "Heart rate variability (HRV) and systemic markers of inflammation have prognostic value in patients with unstable angina pectoris (UAP). However, it is unknown whether any relation exists between HRV parameters and indexes of inflammation in this clinical context. We assessed HRV on 24-hour electrocardiographic Holter recordings, performed within 24 hours of admission, and measured C-reactive protein (CRP) serum levels by a high-sensitivity assay on admission, in 531 patients with UAP (65 ± 10 years of age; 347 men) who were enrolled in the prospective multicenter study Stratificazione Prognostica dell'Angina Instabile (SPAI). A significant inverse correlation was found between CRP levels and all HRV parameters, with the highest r coefficient shown with SD of all RR intervals (r = -0.23; p",
author = "Lanza, {Gaetano A.} and Sgueglia, {Gregory Angelo} and Domenico Cianflone and Rebuzzi, {Antonio G.} and Giulia Angeloni and Alfonso Sestito and Fabio Infusino and Filippo Crea and Attilio Maseri",
year = "2006",
month = "6",
day = "15",
doi = "10.1016/j.amjcard.2006.01.029",
language = "English",
volume = "97",
pages = "1702--1706",
journal = "American Journal of Cardiology",
issn = "0002-9149",
publisher = "Elsevier Inc.",
number = "12",

}

TY - JOUR

T1 - Relation of Heart Rate Variability to Serum Levels of C-Reactive Protein in Patients With Unstable Angina Pectoris

AU - Lanza, Gaetano A.

AU - Sgueglia, Gregory Angelo

AU - Cianflone, Domenico

AU - Rebuzzi, Antonio G.

AU - Angeloni, Giulia

AU - Sestito, Alfonso

AU - Infusino, Fabio

AU - Crea, Filippo

AU - Maseri, Attilio

PY - 2006/6/15

Y1 - 2006/6/15

N2 - Heart rate variability (HRV) and systemic markers of inflammation have prognostic value in patients with unstable angina pectoris (UAP). However, it is unknown whether any relation exists between HRV parameters and indexes of inflammation in this clinical context. We assessed HRV on 24-hour electrocardiographic Holter recordings, performed within 24 hours of admission, and measured C-reactive protein (CRP) serum levels by a high-sensitivity assay on admission, in 531 patients with UAP (65 ± 10 years of age; 347 men) who were enrolled in the prospective multicenter study Stratificazione Prognostica dell'Angina Instabile (SPAI). A significant inverse correlation was found between CRP levels and all HRV parameters, with the highest r coefficient shown with SD of all RR intervals (r = -0.23; p

AB - Heart rate variability (HRV) and systemic markers of inflammation have prognostic value in patients with unstable angina pectoris (UAP). However, it is unknown whether any relation exists between HRV parameters and indexes of inflammation in this clinical context. We assessed HRV on 24-hour electrocardiographic Holter recordings, performed within 24 hours of admission, and measured C-reactive protein (CRP) serum levels by a high-sensitivity assay on admission, in 531 patients with UAP (65 ± 10 years of age; 347 men) who were enrolled in the prospective multicenter study Stratificazione Prognostica dell'Angina Instabile (SPAI). A significant inverse correlation was found between CRP levels and all HRV parameters, with the highest r coefficient shown with SD of all RR intervals (r = -0.23; p

UR - http://www.scopus.com/inward/record.url?scp=33744516030&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33744516030&partnerID=8YFLogxK

U2 - 10.1016/j.amjcard.2006.01.029

DO - 10.1016/j.amjcard.2006.01.029

M3 - Article

C2 - 16765117

AN - SCOPUS:33744516030

VL - 97

SP - 1702

EP - 1706

JO - American Journal of Cardiology

JF - American Journal of Cardiology

SN - 0002-9149

IS - 12

ER -