Relation of Heart Rate Variability to Serum Levels of C-Reactive Protein in Patients With Unstable Angina Pectoris

Gaetano A. Lanza, Gregory Angelo Sgueglia, Domenico Cianflone, Antonio G. Rebuzzi, Giulia Angeloni, Alfonso Sestito, Fabio Infusino, Filippo Crea, Attilio Maseri

Research output: Contribution to journalArticle


Heart rate variability (HRV) and systemic markers of inflammation have prognostic value in patients with unstable angina pectoris (UAP). However, it is unknown whether any relation exists between HRV parameters and indexes of inflammation in this clinical context. We assessed HRV on 24-hour electrocardiographic Holter recordings, performed within 24 hours of admission, and measured C-reactive protein (CRP) serum levels by a high-sensitivity assay on admission, in 531 patients with UAP (65 ± 10 years of age; 347 men) who were enrolled in the prospective multicenter study Stratificazione Prognostica dell'Angina Instabile (SPAI). A significant inverse correlation was found between CRP levels and all HRV parameters, with the highest r coefficient shown with SD of all RR intervals (r = -0.23; p

Original languageEnglish
Pages (from-to)1702-1706
Number of pages5
JournalThe American Journal of Cardiology
Issue number12
Publication statusPublished - Jun 15 2006


ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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