Abstract
To analyze the determinants of left ventricular (LV) performance (myocardial afterload, chamber size, mass, and contractility) in Goldblatt hypertension, 19 anesthetized one-kidney, one-clip (1K1C) and 28 two-kidney, one-clip (2K1C) male Wistar rats were studied 58 to 62 days after clipping, together with 19 sham-operated and 13 normal rats (controls), by M-mode echocardiography using necropsy-validated methods of measurement. The LV fractional shortening was inversely related to end-systolic stress in all groups (r = —0.89 to —0.95, all P `.00001): 7 2K1C (25%) and 9 1K1C (47%) had fractional shortening above the upper confidence limit in control animals. Both 1K1C and 2K1C with high LV performance had severe hypertension, inadequate LV hypertrophy, with resultant high wall stress (both P `.005), increased LV chamber dimension (P `.005 and P `.05, respectively) and high afterload-corrected fractional shortening (both P `.001); 2K1C also had high plasma renin activity and atrial natriuretic factor levels (both P `.01). Rats with normal LV performance exhibited mild hypertension, adequate LV hypertrophy (normalizing wall stress), and normal LV chamber size and afterload-corrected fractional shortening. Thus, 8J weeks after clipping, adequate LV hypertrophy allows maintenance of normal LV function by normalizing myocardial after load in a majority of rats with Goldblatt hypertension, whereas increased LV contractility (and possibly use of preload reserve in 1K1C) maintains normal LV function in the presence of inadequate LV hypertrophy and elevated wall stress, in a substantial minority of rats that developed more severe Goldblatt hypertension. Am J Hypertens 1992;5:292-301.
| Original language | English |
|---|---|
| Pages (from-to) | 292-301 |
| Number of pages | 10 |
| Journal | American Journal of Hypertension |
| Volume | 5 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 1992 |
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Keywords
- Afterload
- Atrial natriuretic factor
- Contractility
- Left ventricular hypertrophy
- Plasma renin activity
ASJC Scopus subject areas
- Internal Medicine
- Cardiology and Cardiovascular Medicine
Cite this
Relation of left ventricular hypertrophy, afterload, and contractility to left ventricular performance in goldblatt hypertension. / Simone, Giovanni De; Devereux, Richard B.; Volpe, Massimo; Camargo, Maria J F; Wallerson, Donald C.; Laragh, John H.
In: American Journal of Hypertension, Vol. 5, No. 5, 1992, p. 292-301.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Relation of left ventricular hypertrophy, afterload, and contractility to left ventricular performance in goldblatt hypertension
AU - Simone, Giovanni De
AU - Devereux, Richard B.
AU - Volpe, Massimo
AU - Camargo, Maria J F
AU - Wallerson, Donald C.
AU - Laragh, John H.
PY - 1992
Y1 - 1992
N2 - To analyze the determinants of left ventricular (LV) performance (myocardial afterload, chamber size, mass, and contractility) in Goldblatt hypertension, 19 anesthetized one-kidney, one-clip (1K1C) and 28 two-kidney, one-clip (2K1C) male Wistar rats were studied 58 to 62 days after clipping, together with 19 sham-operated and 13 normal rats (controls), by M-mode echocardiography using necropsy-validated methods of measurement. The LV fractional shortening was inversely related to end-systolic stress in all groups (r = —0.89 to —0.95, all P `.00001): 7 2K1C (25%) and 9 1K1C (47%) had fractional shortening above the upper confidence limit in control animals. Both 1K1C and 2K1C with high LV performance had severe hypertension, inadequate LV hypertrophy, with resultant high wall stress (both P `.005), increased LV chamber dimension (P `.005 and P `.05, respectively) and high afterload-corrected fractional shortening (both P `.001); 2K1C also had high plasma renin activity and atrial natriuretic factor levels (both P `.01). Rats with normal LV performance exhibited mild hypertension, adequate LV hypertrophy (normalizing wall stress), and normal LV chamber size and afterload-corrected fractional shortening. Thus, 8J weeks after clipping, adequate LV hypertrophy allows maintenance of normal LV function by normalizing myocardial after load in a majority of rats with Goldblatt hypertension, whereas increased LV contractility (and possibly use of preload reserve in 1K1C) maintains normal LV function in the presence of inadequate LV hypertrophy and elevated wall stress, in a substantial minority of rats that developed more severe Goldblatt hypertension. Am J Hypertens 1992;5:292-301.
AB - To analyze the determinants of left ventricular (LV) performance (myocardial afterload, chamber size, mass, and contractility) in Goldblatt hypertension, 19 anesthetized one-kidney, one-clip (1K1C) and 28 two-kidney, one-clip (2K1C) male Wistar rats were studied 58 to 62 days after clipping, together with 19 sham-operated and 13 normal rats (controls), by M-mode echocardiography using necropsy-validated methods of measurement. The LV fractional shortening was inversely related to end-systolic stress in all groups (r = —0.89 to —0.95, all P `.00001): 7 2K1C (25%) and 9 1K1C (47%) had fractional shortening above the upper confidence limit in control animals. Both 1K1C and 2K1C with high LV performance had severe hypertension, inadequate LV hypertrophy, with resultant high wall stress (both P `.005), increased LV chamber dimension (P `.005 and P `.05, respectively) and high afterload-corrected fractional shortening (both P `.001); 2K1C also had high plasma renin activity and atrial natriuretic factor levels (both P `.01). Rats with normal LV performance exhibited mild hypertension, adequate LV hypertrophy (normalizing wall stress), and normal LV chamber size and afterload-corrected fractional shortening. Thus, 8J weeks after clipping, adequate LV hypertrophy allows maintenance of normal LV function by normalizing myocardial after load in a majority of rats with Goldblatt hypertension, whereas increased LV contractility (and possibly use of preload reserve in 1K1C) maintains normal LV function in the presence of inadequate LV hypertrophy and elevated wall stress, in a substantial minority of rats that developed more severe Goldblatt hypertension. Am J Hypertens 1992;5:292-301.
KW - Afterload
KW - Atrial natriuretic factor
KW - Contractility
KW - Left ventricular hypertrophy
KW - Plasma renin activity
UR - http://www.scopus.com/inward/record.url?scp=0026556156&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026556156&partnerID=8YFLogxK
U2 - 10.1093/ajh/5.5.292
DO - 10.1093/ajh/5.5.292
M3 - Article
C2 - 1533770
AN - SCOPUS:0026556156
VL - 5
SP - 292
EP - 301
JO - American Journal of Hypertension
JF - American Journal of Hypertension
SN - 0895-7061
IS - 5
ER -