Relation of the -174 G/C polymorphism of interleukin-6 to interleukin-6 plasma levels and to length of hospitalization after surgical coronary revascularization

Francesco Burzotta; Licia Iacoviello; Augusto Di Castelnuovo; Franco Glieca; Nicola Luciani; Roberto Zamparelli; Rocco Schiavello; Maria Benedetta Donati; Attilio Maseri; GianFederico Possati; Felicita Andreotti

doi:10.1016/S0002-9149(01)02046-X

Relation of the -174 G/C polymorphism of interleukin-6 to interleukin-6 plasma levels and to length of hospitalization after surgical coronary revascularization

Francesco Burzotta, Licia Iacoviello, Augusto Di Castelnuovo, Franco Glieca, Nicola Luciani, Roberto Zamparelli, Rocco Schiavello, Maria Benedetta Donati, Attilio Maseri, GianFederico Possati, Felicita Andreotti

www.neuromed.it

Research output: Contribution to journal › Article › peer-review

Abstract

Interleukin (IL)-6 plasma levels are predictive of major cardiovascular events. The -174 G/C promoter polymorphism of the IL-6 gene affects basal levels in vivo and transcription rates in vitro, but its association with IL-6 acute phase levels among patients with coronary artery disease has not been investigated. In 111 patients with multivessel coronary artery disease undergoing elective coronary artery bypass graft surgery, we prospectively assessed genotype at position -174 and serial blood levels of IL-6 and other inflammatory indexes. Clinical and surgical characteristics did not differ among genotypic groups. IL-6 levels - measured daily up to 72 hours before surgery, after surgery, and at discharge - showed a mean 17-fold increase, peaking at 24 hours (p

Original language	English
Pages (from-to)	1125-1128
Number of pages	4
Journal	The American Journal of Cardiology
Volume	88
Issue number	10
DOIs	https://doi.org/10.1016/S0002-9149(01)02046-X
Publication status	Published - Nov 15 2001

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

Access to Document

10.1016/S0002-9149(01)02046-X

Cite this

Burzotta, F., Iacoviello, L., Di Castelnuovo, A., Glieca, F., Luciani, N., Zamparelli, R., Schiavello, R., Donati, M. B., Maseri, A., Possati, G., & Andreotti, F. (2001). Relation of the -174 G/C polymorphism of interleukin-6 to interleukin-6 plasma levels and to length of hospitalization after surgical coronary revascularization. The American Journal of Cardiology, 88(10), 1125-1128. https://doi.org/10.1016/S0002-9149(01)02046-X

Relation of the -174 G/C polymorphism of interleukin-6 to interleukin-6 plasma levels and to length of hospitalization after surgical coronary revascularization. / Burzotta, Francesco; Iacoviello, Licia; Di Castelnuovo, Augusto; Glieca, Franco; Luciani, Nicola; Zamparelli, Roberto; Schiavello, Rocco; Donati, Maria Benedetta; Maseri, Attilio; Possati, GianFederico; Andreotti, Felicita.

In: The American Journal of Cardiology, Vol. 88, No. 10, 15.11.2001, p. 1125-1128.

Research output: Contribution to journal › Article › peer-review

Burzotta, F, Iacoviello, L, Di Castelnuovo, A, Glieca, F, Luciani, N, Zamparelli, R, Schiavello, R, Donati, MB, Maseri, A, Possati, G & Andreotti, F 2001, 'Relation of the -174 G/C polymorphism of interleukin-6 to interleukin-6 plasma levels and to length of hospitalization after surgical coronary revascularization', The American Journal of Cardiology, vol. 88, no. 10, pp. 1125-1128. https://doi.org/10.1016/S0002-9149(01)02046-X

Burzotta, Francesco ; Iacoviello, Licia ; Di Castelnuovo, Augusto ; Glieca, Franco ; Luciani, Nicola ; Zamparelli, Roberto ; Schiavello, Rocco ; Donati, Maria Benedetta ; Maseri, Attilio ; Possati, GianFederico ; Andreotti, Felicita. / Relation of the -174 G/C polymorphism of interleukin-6 to interleukin-6 plasma levels and to length of hospitalization after surgical coronary revascularization. In: The American Journal of Cardiology. 2001 ; Vol. 88, No. 10. pp. 1125-1128.

@article{bc30492e57254ebba5eff3614cd14d89,

title = "Relation of the -174 G/C polymorphism of interleukin-6 to interleukin-6 plasma levels and to length of hospitalization after surgical coronary revascularization",

abstract = "Interleukin (IL)-6 plasma levels are predictive of major cardiovascular events. The -174 G/C promoter polymorphism of the IL-6 gene affects basal levels in vivo and transcription rates in vitro, but its association with IL-6 acute phase levels among patients with coronary artery disease has not been investigated. In 111 patients with multivessel coronary artery disease undergoing elective coronary artery bypass graft surgery, we prospectively assessed genotype at position -174 and serial blood levels of IL-6 and other inflammatory indexes. Clinical and surgical characteristics did not differ among genotypic groups. IL-6 levels - measured daily up to 72 hours before surgery, after surgery, and at discharge - showed a mean 17-fold increase, peaking at 24 hours (p ",

author = "Francesco Burzotta and Licia Iacoviello and {Di Castelnuovo}, Augusto and Franco Glieca and Nicola Luciani and Roberto Zamparelli and Rocco Schiavello and Donati, {Maria Benedetta} and Attilio Maseri and GianFederico Possati and Felicita Andreotti",

year = "2001",

month = nov,

day = "15",

doi = "10.1016/S0002-9149(01)02046-X",

language = "English",

volume = "88",

pages = "1125--1128",

journal = "American Journal of Cardiology",

issn = "0002-9149",

publisher = "Elsevier Inc.",

number = "10",

}

TY - JOUR

T1 - Relation of the -174 G/C polymorphism of interleukin-6 to interleukin-6 plasma levels and to length of hospitalization after surgical coronary revascularization

AU - Burzotta, Francesco

AU - Iacoviello, Licia

AU - Di Castelnuovo, Augusto

AU - Glieca, Franco

AU - Luciani, Nicola

AU - Zamparelli, Roberto

AU - Schiavello, Rocco

AU - Donati, Maria Benedetta

AU - Maseri, Attilio

AU - Possati, GianFederico

AU - Andreotti, Felicita

PY - 2001/11/15

Y1 - 2001/11/15

N2 - Interleukin (IL)-6 plasma levels are predictive of major cardiovascular events. The -174 G/C promoter polymorphism of the IL-6 gene affects basal levels in vivo and transcription rates in vitro, but its association with IL-6 acute phase levels among patients with coronary artery disease has not been investigated. In 111 patients with multivessel coronary artery disease undergoing elective coronary artery bypass graft surgery, we prospectively assessed genotype at position -174 and serial blood levels of IL-6 and other inflammatory indexes. Clinical and surgical characteristics did not differ among genotypic groups. IL-6 levels - measured daily up to 72 hours before surgery, after surgery, and at discharge - showed a mean 17-fold increase, peaking at 24 hours (p

AB - Interleukin (IL)-6 plasma levels are predictive of major cardiovascular events. The -174 G/C promoter polymorphism of the IL-6 gene affects basal levels in vivo and transcription rates in vitro, but its association with IL-6 acute phase levels among patients with coronary artery disease has not been investigated. In 111 patients with multivessel coronary artery disease undergoing elective coronary artery bypass graft surgery, we prospectively assessed genotype at position -174 and serial blood levels of IL-6 and other inflammatory indexes. Clinical and surgical characteristics did not differ among genotypic groups. IL-6 levels - measured daily up to 72 hours before surgery, after surgery, and at discharge - showed a mean 17-fold increase, peaking at 24 hours (p

UR - http://www.scopus.com/inward/record.url?scp=0035889519&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035889519&partnerID=8YFLogxK

U2 - 10.1016/S0002-9149(01)02046-X

DO - 10.1016/S0002-9149(01)02046-X

M3 - Article

C2 - 11703956

AN - SCOPUS:0035889519

VL - 88

SP - 1125

EP - 1128

JO - American Journal of Cardiology

JF - American Journal of Cardiology

SN - 0002-9149

IS - 10

ER -

Relation of the -174 G/C polymorphism of interleukin-6 to interleukin-6 plasma levels and to length of hospitalization after surgical coronary revascularization

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this