Relation of the -174 G/C polymorphism of interleukin-6 to interleukin-6 plasma levels and to length of hospitalization after surgical coronary revascularization

Francesco Burzotta, Licia Iacoviello, Augusto Di Castelnuovo, Franco Glieca, Nicola Luciani, Roberto Zamparelli, Rocco Schiavello, Maria Benedetta Donati, Attilio Maseri, GianFederico Possati, Felicita Andreotti

Research output: Contribution to journalArticle

Abstract

Interleukin (IL)-6 plasma levels are predictive of major cardiovascular events. The -174 G/C promoter polymorphism of the IL-6 gene affects basal levels in vivo and transcription rates in vitro, but its association with IL-6 acute phase levels among patients with coronary artery disease has not been investigated. In 111 patients with multivessel coronary artery disease undergoing elective coronary artery bypass graft surgery, we prospectively assessed genotype at position -174 and serial blood levels of IL-6 and other inflammatory indexes. Clinical and surgical characteristics did not differ among genotypic groups. IL-6 levels - measured daily up to 72 hours before surgery, after surgery, and at discharge - showed a mean 17-fold increase, peaking at 24 hours (p

Original languageEnglish
Pages (from-to)1125-1128
Number of pages4
JournalThe American Journal of Cardiology
Volume88
Issue number10
DOIs
Publication statusPublished - Nov 15 2001

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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