TY - JOUR
T1 - Relation of the -174 G/C polymorphism of interleukin-6 to interleukin-6 plasma levels and to length of hospitalization after surgical coronary revascularization
AU - Burzotta, Francesco
AU - Iacoviello, Licia
AU - Di Castelnuovo, Augusto
AU - Glieca, Franco
AU - Luciani, Nicola
AU - Zamparelli, Roberto
AU - Schiavello, Rocco
AU - Donati, Maria Benedetta
AU - Maseri, Attilio
AU - Possati, GianFederico
AU - Andreotti, Felicita
PY - 2001/11/15
Y1 - 2001/11/15
N2 - Interleukin (IL)-6 plasma levels are predictive of major cardiovascular events. The -174 G/C promoter polymorphism of the IL-6 gene affects basal levels in vivo and transcription rates in vitro, but its association with IL-6 acute phase levels among patients with coronary artery disease has not been investigated. In 111 patients with multivessel coronary artery disease undergoing elective coronary artery bypass graft surgery, we prospectively assessed genotype at position -174 and serial blood levels of IL-6 and other inflammatory indexes. Clinical and surgical characteristics did not differ among genotypic groups. IL-6 levels - measured daily up to 72 hours before surgery, after surgery, and at discharge - showed a mean 17-fold increase, peaking at 24 hours (p
AB - Interleukin (IL)-6 plasma levels are predictive of major cardiovascular events. The -174 G/C promoter polymorphism of the IL-6 gene affects basal levels in vivo and transcription rates in vitro, but its association with IL-6 acute phase levels among patients with coronary artery disease has not been investigated. In 111 patients with multivessel coronary artery disease undergoing elective coronary artery bypass graft surgery, we prospectively assessed genotype at position -174 and serial blood levels of IL-6 and other inflammatory indexes. Clinical and surgical characteristics did not differ among genotypic groups. IL-6 levels - measured daily up to 72 hours before surgery, after surgery, and at discharge - showed a mean 17-fold increase, peaking at 24 hours (p
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U2 - 10.1016/S0002-9149(01)02046-X
DO - 10.1016/S0002-9149(01)02046-X
M3 - Article
C2 - 11703956
AN - SCOPUS:0035889519
VL - 88
SP - 1125
EP - 1128
JO - American Journal of Cardiology
JF - American Journal of Cardiology
SN - 0002-9149
IS - 10
ER -