Relations of left ventricular mass and systolic function to endothelial function and coronary flow reserve in healthy, new discovered hypertensive subjects

V. Palmieri, G. Storto, E. Arezzi, T. Pellegrino, M. Mancini, G. Di Minno, A. L. Ferrara, A. Cuocolo, A. Celentano

Research output: Contribution to journalArticle

Abstract

Left ventricular hypertrophy (LVH) is prognostically relevant, associated with major cardiovascular risk factors and with atherosclerosis. However, whether LVH is independently associated with impaired coronary flow reserve (CFR) and with endothelial dysfunction is disputed. We assessed the relationship of LV mass and systolic function to CFR and endothelial function in new discovered never treated subjects with essential arterial hypertension, but without coronary artery disease or microalbuminuria. LVH, ejection fraction (EF) and stress-corrected midwall shortening (MWS, a measure of myocardial contractility) were assessed by echocardiography. CFR was assessed by single-photon emission computed tomography and dipyridamole infusion. Endothelial function was evaluated by assessing 1-min postischaemic flow-mediated dilatation of the brachial artery (FMD); nitroglycerine-mediated dilatation (NMD) of the same brachial artery was used as measure of nonendothelium-dependent vasodilatation. In approximately 1 year, we enrolled 21 subjects who met stringent inclusion criteria (47±10 years old, 26.6±2.8kg/m2, 78% men). Five patients showed LVH. Multivariate analyses showed a significant negative correlation of LV mass index with FMD (β =-0.61, P

Original languageEnglish
Pages (from-to)941-950
Number of pages10
JournalJournal of Human Hypertension
Volume19
Issue number12
DOIs
Publication statusPublished - Dec 2005

Keywords

  • Coronary flow reserve
  • Endothelial function
  • Left ventricular hypertrophy
  • Systolic function

ASJC Scopus subject areas

  • Internal Medicine

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