Relationship among body mass index, NT-proBNP, and mortality in decompensated chronic heart failure

Domenico Scrutinio, Andrea Passantino, Pietro Guida, Enrico Ammirati, Fabrizio Oliva, Simona Sarzi Braga, Maria Teresa La Rovere, Rocco Lagioia, Maria Frigerio, Salvatore Di Somma

Research output: Contribution to journalArticlepeer-review


BACKGROUND: Obesity has been suggested to confer a survival benefit in acute heart failure. The concentrations of NT-proBNP may be reduced in patients with high body mass index (BMI).

OBJECTIVES: To investigate the relationship among BMI, NT-proBNP, and mortality risk in decompensated chronic heart failure (DCHF).

METHODS: This was a retrospective study. We studied 1001 patients with DCHF. Hazard ratios (HR) were calculated with Cox regression analysis.

RESULTS: During the 1-year follow-up, 295 patients died. Compared with normal-weight patients, the unadjusted HR for death were 1.02 (95% CIs 0.79-1.33; p = 0.862) for patients with a BMI of 25.0-29.9 kg/m(2) and 0.83 (95% CIs 0.61-1.12; p = 0.213) for patients with a BMI ≥ 30 kg/m(2). NT-proBNP remained independently associated with mortality across the BMI categories. There was no statistically significant interaction between BMI and NT-proBNP levels for risk prediction.

CONCLUSIONS: Obesity was not associated with mortality risk. NT-proBNP remained an independent prognostic factor across the BMI categories.

Original languageEnglish
Pages (from-to)172-177
Number of pages6
JournalHeart and Lung: Journal of Acute and Critical Care
Issue number3
Publication statusPublished - Feb 12 2017


  • Journal Article


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