TY - JOUR
T1 - Relationship among endothelial response to hyperemia, bone marrow-derived progenitor cells, and parathyroid hormone in renal transplantation
AU - Fatini, Cinzia
AU - Sticchi, Elena
AU - Cesari, Francesca
AU - Gori, Anna Maria
AU - Cioni, Gabriele
AU - De Stefano, Margherita
AU - Bertoni, Elisabetta
AU - Paudice, Nunzia
AU - Salvadori, Maurizio
AU - Zanazzi, Maria
AU - Abbate, Rosanna
PY - 2012/4/27
Y1 - 2012/4/27
N2 - BACKGROUND. Endothelial dysfunction may contribute to modulate cardiovascular complications in renal transplant recipients (RTRs), and a relationship between endothelial dysfunction and parathyroid hormone (PTH) levels in RTRs has been demonstrated. We evaluated the relationship between endothelial response to hyperemia and circulating progenitor cells (CPCs) and endothelial progenitor cells (EPCs) PTH, and genetic parameters in RTRs. METHODS. In 120 RTRs and in healthy subjects without (n=107, group A) and with cardiovascular risk factors (n=109, group B), we evaluated endothelial response to hyperemia through digital tonometry (peripheral arterial tonometry) detected by reactive hyperemia index (RHI) and EPCs and CPCs by flow cytometry. RESULTS. In RTRs, RHI median value was lower than in group A (P=0.05). EPC number was significantly lower in RTRs than in groups A and B (PC, 894G>T, and 4a/4b polymorphisms and RHI, EPC, and CPC number was found. CONCLUSIONS. This study shows an altered endothelial response, associated with reduced EPCs, and increased PTH in RTRs; the evaluation of endothelial status in RTRs may contribute to better assess the risk profile of these patients.
AB - BACKGROUND. Endothelial dysfunction may contribute to modulate cardiovascular complications in renal transplant recipients (RTRs), and a relationship between endothelial dysfunction and parathyroid hormone (PTH) levels in RTRs has been demonstrated. We evaluated the relationship between endothelial response to hyperemia and circulating progenitor cells (CPCs) and endothelial progenitor cells (EPCs) PTH, and genetic parameters in RTRs. METHODS. In 120 RTRs and in healthy subjects without (n=107, group A) and with cardiovascular risk factors (n=109, group B), we evaluated endothelial response to hyperemia through digital tonometry (peripheral arterial tonometry) detected by reactive hyperemia index (RHI) and EPCs and CPCs by flow cytometry. RESULTS. In RTRs, RHI median value was lower than in group A (P=0.05). EPC number was significantly lower in RTRs than in groups A and B (PC, 894G>T, and 4a/4b polymorphisms and RHI, EPC, and CPC number was found. CONCLUSIONS. This study shows an altered endothelial response, associated with reduced EPCs, and increased PTH in RTRs; the evaluation of endothelial status in RTRs may contribute to better assess the risk profile of these patients.
KW - CPCs
KW - EPCs
KW - Parathyroid hormone
KW - Peripheral arterial tonometry (PAT)
KW - Renal transplantation
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U2 - 10.1097/TP.0b013e318247a75d
DO - 10.1097/TP.0b013e318247a75d
M3 - Article
C2 - 22343335
AN - SCOPUS:84859630273
VL - 93
SP - 835
EP - 841
JO - Transplantation
JF - Transplantation
SN - 0041-1337
IS - 8
ER -