Relationship between 3-month changes in biochemical markers of bone remodelling and changes in bone mineral density and fracture incidence in patients treated with strontium ranelate for 3 years

O. Bruyère, J. Collette, R. Rizzoli, C. Decock, S. Ortolani, C. Cormier, J. Detilleux, J. Y. Reginster

Research output: Contribution to journalArticlepeer-review

Abstract

From two randomised controlled trials, it is shown that 3-month changes in biochemical markers of bone formation (bone-specific alkaline phosphatase and Cterminal propeptide of type I procollagen) were associated with 3-year bone mineral density (BMD) changes, but not fracture incidence in patients treated with strontium ranelate. Introduction: The purpose of this study was to assess if short-term change in biochemical markers of bone remodelling is associated with long-term BMD change and fracture incidence observed during treatment with strontium ranelate. Methods: From the SOTI and TROPOS trials, bone-specific alkaline phosphatase (BALP), C-terminal propeptide of type I procollagen (PICP), serum C-terminal telopeptides (S-CTX) and urine N-terminal telopeptides of type I collagen (U-NTX) were assessed at baseline and after 3 months. Results: Two thousand three hundred seventy-three women were included in this study. Multiple regression analysis showed that 3-month changes in PICP and BALP but not s-CTX I nor s-NTX I were significantly (p

Original languageEnglish
Pages (from-to)1031-1036
Number of pages6
JournalOsteoporosis International
Volume21
Issue number6
DOIs
Publication statusPublished - Jun 2010

Keywords

  • Biochemical markers
  • Bone mineral density
  • Fracture
  • Strontium ranelate

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

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