Relationship between acceleration of gastric emptying and oesophageal acid exposure in patients with endoscopy-negative gastro-oesophageal reflux disease

Stefania Carmagnola, Mirella Fraquelli, Paolo Cantù, Dario Conte, Roberto Penagini

Research output: Contribution to journalArticle

Abstract

Objective. A delay in gastric emptying has been reported in patients with gastro-oesophageal reflux disease (GORD), but its role in increasing the number of reflux episodes is still debated. The aim of this study was to assess the relationship between acceleration of gastric emptying and gastro-oesophageal reflux in patients with endoscopy-negative GORD and pathological oesophageal acid exposure. Material and methods. Twelve patients (7 M, age range 24-65 years) underwent 6-h postprandial (2.1 MJ meal) combined gastric emptying by real-time ultrasonography and intra-oesophageal pH monitoring after cisapride (20 mg b.i.d.) and placebo for 3 days, on two separate occasions at least 7 days apart in double-blind randomized order. Gastric emptying after placebo was also measured in 12 healthy volunteers (7 M, age range 25-54 years). Results. In the patients' group, the area under the emptying time curve was greater (p 2

Original languageEnglish
Pages (from-to)767-772
Number of pages6
JournalScandinavian Journal of Gastroenterology
Volume41
Issue number7
DOIs
Publication statusPublished - Jul 1 2006

Keywords

  • Cisapride
  • Gastric emptying
  • Gastroesophageal reflux
  • Gastroesophageal reflux disease

ASJC Scopus subject areas

  • Gastroenterology

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