Relationship between adherence to the Mediterranean Diet, intracerebral hemorrhage, and its location

Antonino Tuttolomondo, Domenico Di Raimondo, Alessandra Casuccio, Mariachiara Velardo, Giovanni Salamone, Valentina Arnao, Rosaria Pecoraro, Vittoriano Della Corte, Vincenzo Restivo, Francesca Corpora, Carlo Maida, Irene Simonetta, Anna Cirrincione, Valerio Vassallo, Antonio Pinto

Research output: Contribution to journalArticlepeer-review


Introduction: Although some authors evaluated the relationship between adherence to the Mediterranean Diet (MeDi) and both ischemic and hemorrhagic stroke, hemorrhagic stroke alone is not yet examined. Aims: We conducted a retrospective study to evaluate the relationship between adherence to MeDi and intracerebral hemorrhage (ICH) and different locations of ICH (ganglionic/internal capsule, brainstem/cerebellum, or lobar). Methods: We analyzed charts and collected data of all consecutive patients with ICH admitted to our Internal Medicine Ward from 2005 to 2014. A scale indicating the degree of adherence to the traditional MeDi Score was constructed. Results: When compared with 100 subjects without ICH, 103 subjects with ICH had significantly higher mean values of LDL (91.1 ± 38.7 mg/dl vs. 79.2 ± 34.4 mg/dl; p = 0.031), triglycerides (118.9 ± 62.9 mg/dl vs. 101.6 ± 47.6 mg/dl; p = 0.026), and proteinuria (32.6 ± 50.0 mg/dl vs. 18.1 ± 39.6 mg/dl; p=0.024) and a significantly lower mean MeDi Score (3.9 ± 1.0 vs. 7.0 ± 1.4; p < 0.0001). In a multiple regression analysis, smoking, diastolic blood pressure (DBP), and the MeDi Score remained significantly associated with ICH. We also observed a significantly lower mean MeDi Score in the lobar location group when compared with the ganglionic/internal capsule group (4.3 ± 1.0 vs. 3.5 ± 0.9; p < 0.0005). Discussion: Our findings regarding the higher prevalence of ICH in patients with lower adherence to MeDi may be related to the fact that patients with lower MeDi Score exhibit a worse cardiovascular risk profile with increased risk factors such as hypertension and dyslipidemia.

Original languageEnglish
Pages (from-to)1118-1125
Number of pages8
JournalNutrition, Metabolism and Cardiovascular Diseases
Issue number10
Publication statusPublished - Oct 2019


  • Intracerebral hemorrhage
  • Lobar
  • Mediterranean Diet

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics
  • Cardiology and Cardiovascular Medicine

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