Relationship between anti-apoptotic proteins survivin and Bcl-2, and response to treatment in patients undergoing post-operative RT for laryngeal cancer: A pilot study

Gino Marioni, Alberto Staffieri, Marco Lionello, Giulia Tealdo, Claudia Staffieri, Luciano Giacomelli, Maria Luisa Friso, Roberto Stramare, Giancarlo Ottaviano, Stella Blandamura

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Clinicopathological research has focused on identifying molecular and biological prognostic factors for laryngeal carcinoma (LSCC) treated with post-operative radiotherapy (RT). The aim of this study was to assess the prognostic importance of anti-apoptotic proteins survivin and B-cell lymphoma-2 (Bcl-2) in a series of patients with LSCC who had primary surgery followed by RT. Methods: Thirty-three consecutive patients who underwent primary surgery followed by RT were considered. Survivin nuclear and cytoplasmic expressions and Bcl-2 expression were determined immunohistochemically. Results: The loco-regional recurrence rate was significantly higher among LSCC patients with a nuclear survivin expression >10.0% (P = 0.029), and their disease-free survival (DFS) was shorter than in cases whose nuclear survivin expression was ≤10.0% (P = 0.002). DFS was significantly shorter in cases with a Bcl-2 expression >2.0% than in those whose Bcl-2 expression was ≤2.0% (P = 0.035). Conclusions: Nuclear survivin expression and Bcl-2 expression warrant further investigation as potential predictive biomarkers to enable individualized treatments (e.g. post-operative chemo-radiotherapy instead of RT alone for patients whose LSCCs strongly express nuclear survivin or/and Bcl-2). This preliminary evidence justifies the design of new studies on the association of agents targeting survivin and Bcl-2 with conventional chemotherapeutic agents and RT for advanced LSCC.

Original languageEnglish
Pages (from-to)339-344
Number of pages6
JournalJournal of Oral Pathology and Medicine
Volume42
Issue number4
DOIs
Publication statusPublished - Apr 2013

Keywords

  • Bcl-2
  • Laryngeal carcinoma
  • Post-operative radiotherapy
  • Prognosis
  • Survivin

ASJC Scopus subject areas

  • Cancer Research
  • Pathology and Forensic Medicine
  • Otorhinolaryngology
  • Oral Surgery
  • Periodontics

Fingerprint Dive into the research topics of 'Relationship between anti-apoptotic proteins survivin and Bcl-2, and response to treatment in patients undergoing post-operative RT for laryngeal cancer: A pilot study'. Together they form a unique fingerprint.

Cite this