Relationship between anti-apoptotic proteins survivin and Bcl-2, and response to treatment in patients undergoing post-operative RT for laryngeal cancer

A pilot study

Gino Marioni, Alberto Staffieri, Marco Lionello, Giulia Tealdo, Claudia Staffieri, Luciano Giacomelli, Maria Luisa Friso, Roberto Stramare, Giancarlo Ottaviano, Stella Blandamura

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background: Clinicopathological research has focused on identifying molecular and biological prognostic factors for laryngeal carcinoma (LSCC) treated with post-operative radiotherapy (RT). The aim of this study was to assess the prognostic importance of anti-apoptotic proteins survivin and B-cell lymphoma-2 (Bcl-2) in a series of patients with LSCC who had primary surgery followed by RT. Methods: Thirty-three consecutive patients who underwent primary surgery followed by RT were considered. Survivin nuclear and cytoplasmic expressions and Bcl-2 expression were determined immunohistochemically. Results: The loco-regional recurrence rate was significantly higher among LSCC patients with a nuclear survivin expression >10.0% (P = 0.029), and their disease-free survival (DFS) was shorter than in cases whose nuclear survivin expression was ≤10.0% (P = 0.002). DFS was significantly shorter in cases with a Bcl-2 expression >2.0% than in those whose Bcl-2 expression was ≤2.0% (P = 0.035). Conclusions: Nuclear survivin expression and Bcl-2 expression warrant further investigation as potential predictive biomarkers to enable individualized treatments (e.g. post-operative chemo-radiotherapy instead of RT alone for patients whose LSCCs strongly express nuclear survivin or/and Bcl-2). This preliminary evidence justifies the design of new studies on the association of agents targeting survivin and Bcl-2 with conventional chemotherapeutic agents and RT for advanced LSCC.

Original languageEnglish
Pages (from-to)339-344
Number of pages6
JournalJournal of Oral Pathology and Medicine
Volume42
Issue number4
DOIs
Publication statusPublished - Apr 2013

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Apoptosis Regulatory Proteins
Laryngeal Neoplasms
B-Cell Lymphoma
Radiotherapy
Therapeutics
Disease-Free Survival
Biological Factors
IgA receptor
Biomarkers
Carcinoma
Recurrence
Research

Keywords

  • Bcl-2
  • Laryngeal carcinoma
  • Post-operative radiotherapy
  • Prognosis
  • Survivin

ASJC Scopus subject areas

  • Cancer Research
  • Pathology and Forensic Medicine
  • Otorhinolaryngology
  • Oral Surgery
  • Periodontics

Cite this

Relationship between anti-apoptotic proteins survivin and Bcl-2, and response to treatment in patients undergoing post-operative RT for laryngeal cancer : A pilot study. / Marioni, Gino; Staffieri, Alberto; Lionello, Marco; Tealdo, Giulia; Staffieri, Claudia; Giacomelli, Luciano; Friso, Maria Luisa; Stramare, Roberto; Ottaviano, Giancarlo; Blandamura, Stella.

In: Journal of Oral Pathology and Medicine, Vol. 42, No. 4, 04.2013, p. 339-344.

Research output: Contribution to journalArticle

Marioni, G, Staffieri, A, Lionello, M, Tealdo, G, Staffieri, C, Giacomelli, L, Friso, ML, Stramare, R, Ottaviano, G & Blandamura, S 2013, 'Relationship between anti-apoptotic proteins survivin and Bcl-2, and response to treatment in patients undergoing post-operative RT for laryngeal cancer: A pilot study', Journal of Oral Pathology and Medicine, vol. 42, no. 4, pp. 339-344. https://doi.org/10.1111/jop.12020
Marioni, Gino ; Staffieri, Alberto ; Lionello, Marco ; Tealdo, Giulia ; Staffieri, Claudia ; Giacomelli, Luciano ; Friso, Maria Luisa ; Stramare, Roberto ; Ottaviano, Giancarlo ; Blandamura, Stella. / Relationship between anti-apoptotic proteins survivin and Bcl-2, and response to treatment in patients undergoing post-operative RT for laryngeal cancer : A pilot study. In: Journal of Oral Pathology and Medicine. 2013 ; Vol. 42, No. 4. pp. 339-344.
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abstract = "Background: Clinicopathological research has focused on identifying molecular and biological prognostic factors for laryngeal carcinoma (LSCC) treated with post-operative radiotherapy (RT). The aim of this study was to assess the prognostic importance of anti-apoptotic proteins survivin and B-cell lymphoma-2 (Bcl-2) in a series of patients with LSCC who had primary surgery followed by RT. Methods: Thirty-three consecutive patients who underwent primary surgery followed by RT were considered. Survivin nuclear and cytoplasmic expressions and Bcl-2 expression were determined immunohistochemically. Results: The loco-regional recurrence rate was significantly higher among LSCC patients with a nuclear survivin expression >10.0{\%} (P = 0.029), and their disease-free survival (DFS) was shorter than in cases whose nuclear survivin expression was ≤10.0{\%} (P = 0.002). DFS was significantly shorter in cases with a Bcl-2 expression >2.0{\%} than in those whose Bcl-2 expression was ≤2.0{\%} (P = 0.035). Conclusions: Nuclear survivin expression and Bcl-2 expression warrant further investigation as potential predictive biomarkers to enable individualized treatments (e.g. post-operative chemo-radiotherapy instead of RT alone for patients whose LSCCs strongly express nuclear survivin or/and Bcl-2). This preliminary evidence justifies the design of new studies on the association of agents targeting survivin and Bcl-2 with conventional chemotherapeutic agents and RT for advanced LSCC.",
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AU - Lionello, Marco

AU - Tealdo, Giulia

AU - Staffieri, Claudia

AU - Giacomelli, Luciano

AU - Friso, Maria Luisa

AU - Stramare, Roberto

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AB - Background: Clinicopathological research has focused on identifying molecular and biological prognostic factors for laryngeal carcinoma (LSCC) treated with post-operative radiotherapy (RT). The aim of this study was to assess the prognostic importance of anti-apoptotic proteins survivin and B-cell lymphoma-2 (Bcl-2) in a series of patients with LSCC who had primary surgery followed by RT. Methods: Thirty-three consecutive patients who underwent primary surgery followed by RT were considered. Survivin nuclear and cytoplasmic expressions and Bcl-2 expression were determined immunohistochemically. Results: The loco-regional recurrence rate was significantly higher among LSCC patients with a nuclear survivin expression >10.0% (P = 0.029), and their disease-free survival (DFS) was shorter than in cases whose nuclear survivin expression was ≤10.0% (P = 0.002). DFS was significantly shorter in cases with a Bcl-2 expression >2.0% than in those whose Bcl-2 expression was ≤2.0% (P = 0.035). Conclusions: Nuclear survivin expression and Bcl-2 expression warrant further investigation as potential predictive biomarkers to enable individualized treatments (e.g. post-operative chemo-radiotherapy instead of RT alone for patients whose LSCCs strongly express nuclear survivin or/and Bcl-2). This preliminary evidence justifies the design of new studies on the association of agents targeting survivin and Bcl-2 with conventional chemotherapeutic agents and RT for advanced LSCC.

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