Relationship between autoimmune phenomena and disease stage and therapy in B-cell chronic lymphocytic leukemia

Wilma Barcellini, Silvana Capalbo, Rosa Maria Agostinelli, Francesca Romana Mauro, Achille Ambrosetti, Rossella Calori, Agostino Cortelezzi, Luca Laurenti, Enrico Maria Pogliani, Paola Pedotti, Vincenzo Liso, Gabriella Girelli, Franco Mandelli, Alberto Zanella

Research output: Contribution to journalArticlepeer-review

Abstract

The aim of this multicenter GIMEMA study was to correlate autoimmune complications (AIC) in B-cell chronic lymphocytic leukemia (B-CLL) with stage and therapy. Autoimmune hemolytic anemia (129/194 cases) and autoimmune thrombocytopenia (35/194 cases) were typically present in advanced and multi-treated disease. Age over the median, stage C and first and second line therapy were identified as independent risk factors by multivariate analysis. In contrast, non-hematologic AIC (30/194 cases) and the presence of serological markers of autoimmunity were mostly observed in early B-CLL, suggesting different pathogenic mechanisms underlying hematologic and non-hematologic autoimmune phenomena in B-CLL.

Original languageEnglish
Pages (from-to)1689-1692
Number of pages4
JournalHaematologica
Volume91
Issue number12
Publication statusPublished - Dec 2006

Keywords

  • AIHA
  • AITP
  • Autoimmunity
  • B-CLL
  • Fludarabine

ASJC Scopus subject areas

  • Hematology

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