Relationship between blood pressure and frailty in older hypertensive outpatients

Giorgio Basile, Antonino Catalano, Giuseppe Mandraffino, Giuseppe Maltese, Angela Alibrandi, Giuliana Ciancio, Antonino Lasco, Matteo Cesari

Research output: Contribution to journalArticlepeer-review


Background: The benefits and risks of treating hypertension in old and frail patients are debated. Aim: The aim of the present study is to measure the frailty status in older patients with hypertension and determine the relationships existing between blood pressure (BP) values and frailty. Methods: Frailty was retrospectively assessed by using the frailty index (FI) in 56 hypertensive old outpatients. Patients with an FI > 0.25 were classified as frail. Results: Forty-five out of 56 (80%) had a FI > 0.25. A statistically significant inverse correlation was found between FI and systolic BP (r = −0.319, p = 0.016), orthostatic systolic BP (r = −0.408, p = 0.002), orthostatic diastolic BP (r = −0.299, p = 0.025), and orthostatic pulse pressure (r = −0.297, p = 0.026). Discussion: Frailer subjects appear as over-treated according to current European guidelines. Conclusions: FI can play an important role in the clinical setting by supporting the identification of subjects at risk and allowing an improved provision of adapted and personalized care.

Original languageEnglish
Pages (from-to)1049-1053
Number of pages5
JournalAging clinical and experimental research
Issue number5
Publication statusPublished - Oct 1 2017


  • Blood pressure
  • Elderly
  • Frailty
  • Frailty index
  • Hypertension

ASJC Scopus subject areas

  • Ageing
  • Geriatrics and Gerontology


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