Relationship between blood pressure, sleep K-complexes, and muscle sympathetic nerve activity in humans

Jens Tank, Andre Diedrich, Nanette Hale, Faiz E. Niaz, Raffaello Furlan, Rose Marie Robertson, Rogelio Mosqueda-Garcia

Research output: Contribution to journalArticlepeer-review

Abstract

Stage 2 sleep is characterized by the EEG appearance of "K-complexes" and blood pressure oscillations. K-complexes may be directly related to blood pressure changes or they may reflect central sympathetic activation. We analyzed the temporal relationship among K-complexes, heart rate (HR), blood pressure (BP), and muscle sympathetic nerve activity (MSNA) during sleep in eight healthy volunteers (3 men and 5 women, age 22-41 yr). Most K-complexes presented as single large complexes (56 ± 20%), followed by single small complexes (15 ± 14%) and as couplets or triplets (13 ± 6%). Single large K-complexes were preceded by a baroreflex-mediated increase of MSNA in approximately one-half (55%) of the cases. Detailed analysis of HR, BP, and MSNA was possible in 63 (45%) large single K-complexes not disturbed by preceding baroreflex-related changes. Systolic and diastolic BP and MSNA increased significantly after single events (22.5 ± 13, 5.2 ± 2.1, and 6.5 ± 3.0%). Mean sympathetic baroreflex latency was similar after the single large K-complexes compared with the mean value during stage 2 sleep (1,290 ± 126 vs. 1,279 ± 61 ms). The area under the burst was significantly increased after single large K-complexes (median 3.9 vs. 9.0 arbitrary units, P <0.03). The results support the hypothesis that K-complexes express cortical activation leading to temporary facilitation of sympathetic outflow in a graded fashion. Their functional effects appear to be independent of baroreflex modulation of MSNA in ∼50% of the cases.

Original languageEnglish
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume285
Issue number1 54-1
Publication statusPublished - Jul 1 2003

Keywords

  • Autonomic nervous system
  • Baroreflex
  • Cardiovascular physiology

ASJC Scopus subject areas

  • Physiology

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