Relationship between blood viscosity and infarct size in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention

Emanuele Cecchi, Agatina Alessandriello Liotta, Anna Maria Gori, Serafina Valente, Cristina Giglioli, Chiara Lazzeri, Francesco Sofi, Gian Franco Gensini, Rosanna Abbate, Lucia Mannini

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Previous studies explored the association between hemorheological alterations and acute myocardial infarction, pointing out the role of hematological components on microvascular flow. The aim of this study was to evaluate the association between blood viscosity and infarct size, estimated by creatine kinase (CK) peak activity and cardiac Troponin I (cTnI) peak concentration in ST-segment elevation myocardial infarction (STEMI) patients after primary percutaneous coronary intervention (PCI). Methods: The study population included 197 patients with diagnosis of STEMI undergoing PCI. Hemorheological studies were performed by assessing whole blood viscosity (measured at shear rates of 0.512 s- 1 and 94.5 s- 1) and plasma viscosity using the Rotational Viscosimeter LS 30 and erythrocyte deformability index by Myrenne filtrometer. Results: Significant correlations between CK peak activity, cTnI peak concentration, left ventricular ejection fraction and hemorheological variables were observed. At linear regression analysis (adjusted for age, gender, traditional cardiovascular risk factors, renal dysfunction, timeliness of reperfusion, pre-PCI TIMI flow, infarct location, multivessel disease and previous coronary artery disease) leukocytes and whole blood viscosity at 0.512 s- 1 and 94.5 s- 1 were independently and positively associated with infarct size. Conclusions: These results demonstrate a significant and independent association between hemorheology and infarct size in STEMI patients after PCI suggesting that blood viscosity, in a condition of low flow, might worsen myocardial perfusion leading to an increased infarct size. The measurement of whole blood viscosity in STEMI patients could help to identify those who may benefit from new therapeutic strategies.

Original languageEnglish
Pages (from-to)189-194
Number of pages6
JournalInternational Journal of Cardiology
Volume134
Issue number2
DOIs
Publication statusPublished - May 15 2009

Keywords

  • Acute myocardial infarction
  • Blood viscosity
  • Infarct size

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Relationship between blood viscosity and infarct size in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention'. Together they form a unique fingerprint.

Cite this