Relationship between body composition, growth hormone and ghrelin secretion in morbidly obese subjects before and after surgically induced weight loss

Sara Farnetti, M. E. Valera Mora, N. Malandrino, M. Manco, A. Iaconelli, C. Guidone, G. Gasbarrini, E. Capristo, G. Mingrone

Research output: Contribution to journalArticle

Abstract

Objective: The aim of the present study was to evaluate the relationship between body composition, ghrelin and growth hormone (GH) following a GHRH/arginine test in severely obese patients before and after surgically induced weight loss. Materials and methods: Fourteen morbidly obese women (age 36±4 years, BMI 47.8±3.2 kg/m2) were studied at baseline and 18 months after biliopancreatic diversion (BPD) with a stable body weight (±2 kg over a 6-month period) and with a BMI of 31.5±2.5 kg/m2. Body composition was measured by anthropometry and dual-energy X-ray absorptiometry. A GHRH/arginine test was performed before and 18 months after BPD to evaluate ghrelin and GH interactions. Active ghrelin and GH were measured by a RIA and chemiluminescence assay, respectively. Results: Fasting serum GH levels and GH area under the curve (AUC) significantly increased from 0.25±0.05 ng/mL to 1.02±0.08 ng/mL (p

Original languageEnglish
Pages (from-to)73-78
Number of pages6
JournalNutritional Therapy and Metabolism
Volume25
Issue number2
Publication statusPublished - Apr 2007

Keywords

  • Biliopancreatic diversion
  • Ghrelin
  • GHRH/arginine test
  • Growth hormone
  • Morbid obesity

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Nutrition and Dietetics

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    Farnetti, S., Valera Mora, M. E., Malandrino, N., Manco, M., Iaconelli, A., Guidone, C., Gasbarrini, G., Capristo, E., & Mingrone, G. (2007). Relationship between body composition, growth hormone and ghrelin secretion in morbidly obese subjects before and after surgically induced weight loss. Nutritional Therapy and Metabolism, 25(2), 73-78.