Relationship Between Brain Amyloid Deposition and Instrumental Activities of Daily Living in Older Adults: A Longitudinal Study from the Multidomain Alzheimer Prevention Trial

and the MAPT/DSA study group

Research output: Contribution to journalArticle

Abstract

Objectives: To examine the evolution of instrumental activity of daily living (IADL) performance according to the presence of brain amyloid deposition. Design: Longitudinal analysis of a randomized controlled trial. Setting: Neuroimaging ancillary study from the Multidomain Alzheimer Prevention Trial (MAPT). Participants: Community-dwelling individuals aged 70 and older without dementia (N = 269; 60% female, mean age 75±4). Measurements: Linear mixed models were used to assess the 36-month evolution of the performance of an IADL questionnaire for primary prevention studies in dementia, the Activity of Daily Living Prevention Instrument (ADL-PI), according to the presence of amyloid deposition using florbetapir positron emission tomography (PET) (standardized uptake value≥1.17). Additional analyses were also conducted to examine the changes in specific domains of daily functioning with and without adjustment for age, sex, apolipoprotein E, randomization group, and time between baseline and PET examination. Results: One hundred two (37.9%) participants were amyloid positive. Amyloid-negative participants had statistically significant improvement in ADL-PI total score between baseline and 36 months (p=.04). The difference after 3 years between amyloid-positive and -negative participants was not significant (β=–0.95±0.53 at 36 months, p=.08; adjusted models: β=–1.07±0.56, p=.06). Amyloid-negative participants also improved in memory-related IADLs (p<.001) throughout the study, unlike amyloid-positive participants. Conclusion: Amyloid-positive and -negative older adults are likely to have different trajectories in IADL performance. Future research is needed to better understand the relationship between amyloid plaques and functional limitations.

Original languageEnglish
Pages (from-to)1940-1947
JournalJournal of the American Geriatrics Society
Volume66
Issue number10
DOIs
Publication statusPublished - 2018

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Activities of Daily Living
Amyloid
Longitudinal Studies
Brain
Positron-Emission Tomography
Dementia
Independent Living
Amyloid Plaques
Apolipoproteins E
Primary Prevention
Random Allocation
Neuroimaging
Linear Models
Randomized Controlled Trials

Keywords

  • Alzheimer's disease
  • amyloid plaques
  • IADL
  • PET scanner

ASJC Scopus subject areas

  • Geriatrics and Gerontology

Cite this

@article{c1673b8ec123483ab9939461900004f5,
title = "Relationship Between Brain Amyloid Deposition and Instrumental Activities of Daily Living in Older Adults: A Longitudinal Study from the Multidomain Alzheimer Prevention Trial",
abstract = "Objectives: To examine the evolution of instrumental activity of daily living (IADL) performance according to the presence of brain amyloid deposition. Design: Longitudinal analysis of a randomized controlled trial. Setting: Neuroimaging ancillary study from the Multidomain Alzheimer Prevention Trial (MAPT). Participants: Community-dwelling individuals aged 70 and older without dementia (N = 269; 60{\%} female, mean age 75±4). Measurements: Linear mixed models were used to assess the 36-month evolution of the performance of an IADL questionnaire for primary prevention studies in dementia, the Activity of Daily Living Prevention Instrument (ADL-PI), according to the presence of amyloid deposition using florbetapir positron emission tomography (PET) (standardized uptake value≥1.17). Additional analyses were also conducted to examine the changes in specific domains of daily functioning with and without adjustment for age, sex, apolipoprotein E, randomization group, and time between baseline and PET examination. Results: One hundred two (37.9{\%}) participants were amyloid positive. Amyloid-negative participants had statistically significant improvement in ADL-PI total score between baseline and 36 months (p=.04). The difference after 3 years between amyloid-positive and -negative participants was not significant (β=–0.95±0.53 at 36 months, p=.08; adjusted models: β=–1.07±0.56, p=.06). Amyloid-negative participants also improved in memory-related IADLs (p<.001) throughout the study, unlike amyloid-positive participants. Conclusion: Amyloid-positive and -negative older adults are likely to have different trajectories in IADL performance. Future research is needed to better understand the relationship between amyloid plaques and functional limitations.",
keywords = "Alzheimer's disease, amyloid plaques, IADL, PET scanner",
author = "{and the MAPT/DSA study group} and Matthieu Lilamand and Matteo Cesari and Christelle Cantet and Pierre Payoux and Sandrine Andrieu and Bruno Vellas",
year = "2018",
doi = "10.1111/jgs.15497",
language = "English",
volume = "66",
pages = "1940--1947",
journal = "Journal of the American Geriatrics Society",
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T1 - Relationship Between Brain Amyloid Deposition and Instrumental Activities of Daily Living in Older Adults

T2 - A Longitudinal Study from the Multidomain Alzheimer Prevention Trial

AU - and the MAPT/DSA study group

AU - Lilamand, Matthieu

AU - Cesari, Matteo

AU - Cantet, Christelle

AU - Payoux, Pierre

AU - Andrieu, Sandrine

AU - Vellas, Bruno

PY - 2018

Y1 - 2018

N2 - Objectives: To examine the evolution of instrumental activity of daily living (IADL) performance according to the presence of brain amyloid deposition. Design: Longitudinal analysis of a randomized controlled trial. Setting: Neuroimaging ancillary study from the Multidomain Alzheimer Prevention Trial (MAPT). Participants: Community-dwelling individuals aged 70 and older without dementia (N = 269; 60% female, mean age 75±4). Measurements: Linear mixed models were used to assess the 36-month evolution of the performance of an IADL questionnaire for primary prevention studies in dementia, the Activity of Daily Living Prevention Instrument (ADL-PI), according to the presence of amyloid deposition using florbetapir positron emission tomography (PET) (standardized uptake value≥1.17). Additional analyses were also conducted to examine the changes in specific domains of daily functioning with and without adjustment for age, sex, apolipoprotein E, randomization group, and time between baseline and PET examination. Results: One hundred two (37.9%) participants were amyloid positive. Amyloid-negative participants had statistically significant improvement in ADL-PI total score between baseline and 36 months (p=.04). The difference after 3 years between amyloid-positive and -negative participants was not significant (β=–0.95±0.53 at 36 months, p=.08; adjusted models: β=–1.07±0.56, p=.06). Amyloid-negative participants also improved in memory-related IADLs (p<.001) throughout the study, unlike amyloid-positive participants. Conclusion: Amyloid-positive and -negative older adults are likely to have different trajectories in IADL performance. Future research is needed to better understand the relationship between amyloid plaques and functional limitations.

AB - Objectives: To examine the evolution of instrumental activity of daily living (IADL) performance according to the presence of brain amyloid deposition. Design: Longitudinal analysis of a randomized controlled trial. Setting: Neuroimaging ancillary study from the Multidomain Alzheimer Prevention Trial (MAPT). Participants: Community-dwelling individuals aged 70 and older without dementia (N = 269; 60% female, mean age 75±4). Measurements: Linear mixed models were used to assess the 36-month evolution of the performance of an IADL questionnaire for primary prevention studies in dementia, the Activity of Daily Living Prevention Instrument (ADL-PI), according to the presence of amyloid deposition using florbetapir positron emission tomography (PET) (standardized uptake value≥1.17). Additional analyses were also conducted to examine the changes in specific domains of daily functioning with and without adjustment for age, sex, apolipoprotein E, randomization group, and time between baseline and PET examination. Results: One hundred two (37.9%) participants were amyloid positive. Amyloid-negative participants had statistically significant improvement in ADL-PI total score between baseline and 36 months (p=.04). The difference after 3 years between amyloid-positive and -negative participants was not significant (β=–0.95±0.53 at 36 months, p=.08; adjusted models: β=–1.07±0.56, p=.06). Amyloid-negative participants also improved in memory-related IADLs (p<.001) throughout the study, unlike amyloid-positive participants. Conclusion: Amyloid-positive and -negative older adults are likely to have different trajectories in IADL performance. Future research is needed to better understand the relationship between amyloid plaques and functional limitations.

KW - Alzheimer's disease

KW - amyloid plaques

KW - IADL

KW - PET scanner

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