Relationship between brain MRI lesion load and short-term disease evolution in non-disabling MS: A large-scale, multicentre study

Marco Rovaris, Maria A. Rocca, Frederik Barkhof, Massimiliano Calabrese, Nicola De Stefano, Michael Khalil, Franz Fazekas, Leonora Fisniku, Paolo Gallo, David H. Miller, Xavier Montalban, Chris Polman, Alex Rovira, Madeleine H. Sombekke, Maria Pia Sormani, Maria Laura Stromillo, Massimo Filippi

Research output: Contribution to journalArticle

Abstract

Background and Objectives: We evaluated clinical and conventional MRI features of a large population of patients with non-disabling MS to identify potential markers of a benign disease course. Methods: In seven MAGNIMS centres we retrospectively identified 182 patients with benign (B) MS (EDSS score ≥3.0, disease duration ≥15 years) and 187 patients with non-disabling relapsing-remitting MS (NDRRMS) (Expanded Disability Status Scale score ≥3.0, disease duration between 5 and 14 years), in whom clinical data were collected within two weeks from a brain T2-weighted scan. Brain T2 lesion volume (LV) was measured in all patients. In 146 BMS and 146 NDRRMS patients, clinical data were also available after a median follow up of 29 months (range: 7-104 months). Results: Mean LV was higher in BMS than in NDRRMS patients (p <0.001), but the mean ratio between LV and disease duration was higher in NDRRMS than in BMS patients (1.1 vs. 0.6 ml/year, p <0.001). In BMS patients, brain LV was correlated with EDSS score increase at follow up (r = 0.18, p = 0.03). Conclusions: An overall low rate of brain LV increase during a long-lasting disease course might be a feature of BMS. In BMS patients, a high brain LV might be associated with worsening of locomotor disability at short-term follow up.

Original languageEnglish
Pages (from-to)319-326
Number of pages8
JournalMultiple Sclerosis Journal
Volume17
Issue number3
DOIs
Publication statusPublished - 2011

Keywords

  • benign
  • disability
  • MRI
  • multicentre
  • multiple sclerosis

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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    Rovaris, M., Rocca, M. A., Barkhof, F., Calabrese, M., De Stefano, N., Khalil, M., Fazekas, F., Fisniku, L., Gallo, P., Miller, D. H., Montalban, X., Polman, C., Rovira, A., Sombekke, M. H., Sormani, M. P., Stromillo, M. L., & Filippi, M. (2011). Relationship between brain MRI lesion load and short-term disease evolution in non-disabling MS: A large-scale, multicentre study. Multiple Sclerosis Journal, 17(3), 319-326. https://doi.org/10.1177/1352458510388824