Relationship between brain structure and Cerebral Visual Impairment in children with Cerebral Palsy: A systematic review: Research in Developmental Disabilities

S.S. Philip, A. Guzzetta, O. Chorna, G. Gole, R.N. Boyd

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Cerebral Visual Impairment (CVI) is very common yet often unrecognised visual dysfunction in children with Cerebral Palsy (CP). Magnetic Resonance Imaging (MRI) is the diagnostic tool in the investigation of brain lesions in children with CP and CVI. Aim: The aim of this systematic review is to evaluate the relationship between brain structure and CVI, as determined by MRI in children with CP. Methods and procedures: A comprehensive search of 5 database (PubMed, EMBASE, SCOPUS, CINAHL and Cochrane Database) was undertaken up until June 2019. The PRISMA checklist was then utilised to report on the process of selecting eligible papers. A total of 30 observational studies met the full inclusion criteria. Further, STROBE checklist was employed to report on the observational studies. Outcomes and results: Periventricular leucomalacia on MRI was found to have a strong association with CVI in all 30 studies. Only 13 (43 %) studies described dorsal and/ ventral stream dysfunction. There was ambiguity in the definition of CVI. Conclusions and implications: The overall level of evidence correlating different patterns of CVI and CP (based on GMFCS, motor type and distribution) and MRI was low. Further studies utilising advances in MRI are needed to understand brain reorganisation and patterns of CVI and suggest rehabilitation therapy inclusive of vision. © 2020 Elsevier Ltd
Original languageEnglish
JournalRes. Dev. Disabil.
Volume99
DOIs
Publication statusPublished - 2020

Keywords

  • Brain structure and function
  • Cerebral palsy
  • Cerebral visual impairment
  • Children
  • Magnetic resonance imaging
  • brain dysfunction
  • brain malformation
  • central nervous system disease
  • cerebral palsy
  • cerebral Visual Impairment
  • clinical feature
  • clinical protocol
  • diffusion tensor imaging
  • disease severity
  • functional assessment
  • functional magnetic resonance imaging
  • grey matter lesion
  • human
  • leukomalacia
  • neuroanatomy
  • outcome assessment
  • Review
  • systematic review
  • visual impairment
  • white matter lesion

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