Relationship between carotid artery mechanics and the spontaneous baroreflex: A noninvasive investigation in normal humans

Daniela Lucini, Carlo Palombo, Mara Malacarne, Massimo Pagani

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: This study addressed the relationship between spontaneous baroreflex sensitivity and carotid mechanical properties in a clinical setting. Methods: In 191 normal volunteers (age range 20-60 years, mean 44±13), spontaneous indices of baroreflex regulation were obtained noninvasively in the time (baroreflex slope, BRS) and frequency domains (α index and systolic arterial pressure-RR interval transfer gain) as well as using an exogenous autoregressive causal model (A.XAR); carotid mechanical properties were estimated by ultrasound. The link between mechanical measures and spontaneous baroreflex indices was explored by multivariate analysis and linear modeling. Results: Participants were divided into five groups according to age decades. With advancing age we observed a decrease in spontaneous baroreflex indices (BRS from 31.2 to 16.3; α index from 27.4 to 13.6; RR-SAP gain at high frequency from 31±3.0 to 14±3.0ms/mmHg all P

Original languageEnglish
Pages (from-to)1809-1816
Number of pages8
JournalJournal of Hypertension
Volume30
Issue number9
DOIs
Publication statusPublished - Sep 2012

Keywords

  • arterial modeling
  • autonomic regulation
  • carotid mechanics
  • multivariate statistics
  • ultrasound

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

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