TY - JOUR
T1 - Relationship between corticotropin-releasing factor and interleukin-2
T2 - Evolutionary evidence
AU - Ottaviani, Enzo
AU - Franchini, Antonella
AU - Caselgrandi, Eva
AU - Cossarizza, Andrea
AU - Franceschi, Claudio
PY - 1994/8/29
Y1 - 1994/8/29
N2 - The addition of corticotropin-releasing factor (CRF) to molluscan hemocytes induces the release of biogenic amines (norepinephrine, epinephrine, dopamine), a phenomenon we have considered as an ancestral type of stress response [(1992) Gen. Comp. Endocrinol. 87, 354-360]. A similar but less significant response was observed following the addition of interleukin-2 (IL-2). Pre-incubation of hemocytes with IL-2 or anti-IL-2 monoclonal antibody significantly reduced or completely eliminated the CRF-induced release of biogenic amines. Further direct evidence of competition between CRF and IL-2 was revealed by immunocytochemical and cytofluorimetric analysis. The data are compatible with the presence of a unique (ancestral?) receptor on molluscan hemocytes, capable of binding both CRF and IL-2, two key molecules of the neuroendocrine and immune system, respectively.
AB - The addition of corticotropin-releasing factor (CRF) to molluscan hemocytes induces the release of biogenic amines (norepinephrine, epinephrine, dopamine), a phenomenon we have considered as an ancestral type of stress response [(1992) Gen. Comp. Endocrinol. 87, 354-360]. A similar but less significant response was observed following the addition of interleukin-2 (IL-2). Pre-incubation of hemocytes with IL-2 or anti-IL-2 monoclonal antibody significantly reduced or completely eliminated the CRF-induced release of biogenic amines. Further direct evidence of competition between CRF and IL-2 was revealed by immunocytochemical and cytofluorimetric analysis. The data are compatible with the presence of a unique (ancestral?) receptor on molluscan hemocytes, capable of binding both CRF and IL-2, two key molecules of the neuroendocrine and immune system, respectively.
KW - Biogenic amines
KW - Corticotropin-releasing factor
KW - Cytokine receptor
KW - Interleukin-2
KW - Molluscan hemocyte
KW - Stress response
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U2 - 10.1016/0014-5793(94)00802-7
DO - 10.1016/0014-5793(94)00802-7
M3 - Article
C2 - 8076685
AN - SCOPUS:0028169880
VL - 351
SP - 19
EP - 21
JO - FEBS Letters
JF - FEBS Letters
SN - 0014-5793
IS - 1
ER -