Relationship between corticotropin-releasing factor and interleukin-2: Evolutionary evidence

Enzo Ottaviani, Antonella Franchini, Eva Caselgrandi, Andrea Cossarizza, Claudio Franceschi

Research output: Contribution to journalArticlepeer-review


The addition of corticotropin-releasing factor (CRF) to molluscan hemocytes induces the release of biogenic amines (norepinephrine, epinephrine, dopamine), a phenomenon we have considered as an ancestral type of stress response [(1992) Gen. Comp. Endocrinol. 87, 354-360]. A similar but less significant response was observed following the addition of interleukin-2 (IL-2). Pre-incubation of hemocytes with IL-2 or anti-IL-2 monoclonal antibody significantly reduced or completely eliminated the CRF-induced release of biogenic amines. Further direct evidence of competition between CRF and IL-2 was revealed by immunocytochemical and cytofluorimetric analysis. The data are compatible with the presence of a unique (ancestral?) receptor on molluscan hemocytes, capable of binding both CRF and IL-2, two key molecules of the neuroendocrine and immune system, respectively.

Original languageEnglish
Pages (from-to)19-21
Number of pages3
JournalFEBS Letters
Issue number1
Publication statusPublished - Aug 29 1994


  • Biogenic amines
  • Corticotropin-releasing factor
  • Cytokine receptor
  • Interleukin-2
  • Molluscan hemocyte
  • Stress response

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology


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