TY - JOUR
T1 - Relationship between cytotoxic necrotizing factor production and serotype in hemolytic Escherichia coli
AU - Caprioli, A.
AU - Falbo, V.
AU - Ruggeri, F. M.
AU - Minelli, F.
AU - Orskov, I.
AU - Donelli, G.
PY - 1989
Y1 - 1989
N2 - We examined the relationship between serotype and cytotoxic necrotizing factor (CNF) production in 123 hemolytic strains of Escherichia coli isolated from both stools and extraintestinal infections. Of 76 strains producing both hemolysin (Hly) and CNF, 66 (87%) belonged to one of six serogroups (02, 04, 06, 022, 075, and 083). In contrast, 47 E. coli strains producing Hly only belonged to 21 different 0 serogroups, and only 2 of these (06 and 018ac) were widely represented. Generally, CNF-positive and CNF-negative hemolytic isolates were assigned to different 0 serogroups, with the exception of 06, often present in both categories of isolates. Serogroups 04 and 018ac were significantly more prevalent among strains from extraintestinal infections than among those from stools. In contrast, the Hly-positive, CNF-negative isolates, belonging to numerous less common serogroups, were hardly ever isolated from extraintestinal infections. Serological typing further confirmed that hemolytic isolates of E. coli may grossly be divided into two main populations on the basis of the ability to produce CNF. Examination of hemolytic E. coli for this property may also be useful in achieving a more detailed characterization of pathogenic clones.
AB - We examined the relationship between serotype and cytotoxic necrotizing factor (CNF) production in 123 hemolytic strains of Escherichia coli isolated from both stools and extraintestinal infections. Of 76 strains producing both hemolysin (Hly) and CNF, 66 (87%) belonged to one of six serogroups (02, 04, 06, 022, 075, and 083). In contrast, 47 E. coli strains producing Hly only belonged to 21 different 0 serogroups, and only 2 of these (06 and 018ac) were widely represented. Generally, CNF-positive and CNF-negative hemolytic isolates were assigned to different 0 serogroups, with the exception of 06, often present in both categories of isolates. Serogroups 04 and 018ac were significantly more prevalent among strains from extraintestinal infections than among those from stools. In contrast, the Hly-positive, CNF-negative isolates, belonging to numerous less common serogroups, were hardly ever isolated from extraintestinal infections. Serological typing further confirmed that hemolytic isolates of E. coli may grossly be divided into two main populations on the basis of the ability to produce CNF. Examination of hemolytic E. coli for this property may also be useful in achieving a more detailed characterization of pathogenic clones.
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M3 - Article
C2 - 2656748
AN - SCOPUS:0024593225
VL - 27
SP - 758
EP - 761
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
SN - 0095-1137
IS - 4
ER -