TY - JOUR
T1 - Relationship between damage to the cerebellar peduncles and clinical disability in multiple sclerosis
AU - Preziosa, Paolo
AU - Rocca, Maria A.
AU - Mesaros, Sarlota
AU - Pagani, Elisabetta
AU - Drulovic, Jelena
AU - Stosic-Opincal, Tatjana
AU - Dackovic, Jelena
AU - Copetti, Massimiliano
AU - Caputo, Domenico
AU - Filippi, Massimo
PY - 2014
Y1 - 2014
N2 - Purpose: To assess whether a structural disconnection between the cerebellum and the cerebral hemispheres contributes to cerebellar and brainstem symptoms in multiple sclerosis (MS). Materials and Methods: This study was approved by the local ethics committee, and written informed consent was obtained from each participant. Brain T2 lesion load, cerebellar white matter and gray matter volumes, and tract-specific measures of the middle and superior cerebellar peduncles were derived from 172 patients with MS and 46 control subjects. Predictors of clinical impairment, which was determined at ambulation and with cerebellar and brainstem functional system scores, were identified by using random forest analysis. Results: Of the 172 patients, 112 (65%) had middle cerebellar peduncle T2 lesions and 74 (43%) had superior cerebellar peduncle T2 lesions. T2 lesions in the middle and superior cerebellar peduncles were more common in clinically impaired patients than in unimpaired patients (P =.05 to
AB - Purpose: To assess whether a structural disconnection between the cerebellum and the cerebral hemispheres contributes to cerebellar and brainstem symptoms in multiple sclerosis (MS). Materials and Methods: This study was approved by the local ethics committee, and written informed consent was obtained from each participant. Brain T2 lesion load, cerebellar white matter and gray matter volumes, and tract-specific measures of the middle and superior cerebellar peduncles were derived from 172 patients with MS and 46 control subjects. Predictors of clinical impairment, which was determined at ambulation and with cerebellar and brainstem functional system scores, were identified by using random forest analysis. Results: Of the 172 patients, 112 (65%) had middle cerebellar peduncle T2 lesions and 74 (43%) had superior cerebellar peduncle T2 lesions. T2 lesions in the middle and superior cerebellar peduncles were more common in clinically impaired patients than in unimpaired patients (P =.05 to
UR - http://www.scopus.com/inward/record.url?scp=84901650327&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84901650327&partnerID=8YFLogxK
U2 - 10.1148/radiol.13132142
DO - 10.1148/radiol.13132142
M3 - Article
C2 - 24555637
AN - SCOPUS:84901650327
VL - 271
SP - 822
EP - 830
JO - Radiology
JF - Radiology
SN - 0033-8419
IS - 3
ER -