Abstract
Aims: In patients with non-ST-elevation acute coronary syndromes (NSTE-ACS) treated with PCI, high (H) platelet reactivity (PR) significantly affects one-year outcome. The aim of this report was to analyse the relationships between HPR, the SYNTAX score (SS) and one-year major adverse cardiac events (MACE: cardiac death, myocardial infarction, stent thrombosis) according to diabetes mellitus (DM) status in patients included in the GEne Polymorphism, Platelet REactivity, and the Syntax Score (GEPRESS) study. Methods and results: PR was measured using the vasodilator-stimulated phosphoprotein (VASP) assay at three time points (before PCI, at hospital discharge and at one month after PCI), with HPR defined as >50% PR index in 1,042 patients treated with aspirin and clopidogrel for one year after PCI. Patients with DM and an SS ¡Ý15 had the highest MACE rate between one month and one year, further increased by the presence of HPR (16.4%). On the other hand, among all patients with an SS
Original language | English |
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Pages (from-to) | 312-318 |
Number of pages | 7 |
Journal | EuroIntervention |
Volume | 12 |
Issue number | 3 |
DOIs | |
Publication status | Published - Jun 1 2016 |
Keywords
- Acute coronary syndromes
- Clopidogrel
- Diabetes
- SYNTAX score
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine