Relationship between diabetes, platelet reactivity, and the SYNTAX score to one-year clinical outcome in patients with non-ST-segment elevation acute coronary syndrome undergoing percutaneous coronary intervention

Stefano De Servi, Gabriele Crimi, Paolo Calabrò, Federico Piscione, Marco Cattaneo, Diego Maffeo, Anna Toso, Antonio Bartorelli, Cataldo Palmieri, Marco De Carlo, Davide Capodanno, Chiara Barozzi, Luciana Tomasi, D. Riva, Dominick J. Angiolillo, Tullio Palmerini

Research output: Contribution to journalArticle

Abstract

Aims: In patients with non-ST-elevation acute coronary syndromes (NSTE-ACS) treated with PCI, high (H) platelet reactivity (PR) significantly affects one-year outcome. The aim of this report was to analyse the relationships between HPR, the SYNTAX score (SS) and one-year major adverse cardiac events (MACE: cardiac death, myocardial infarction, stent thrombosis) according to diabetes mellitus (DM) status in patients included in the GEne Polymorphism, Platelet REactivity, and the Syntax Score (GEPRESS) study. Methods and results: PR was measured using the vasodilator-stimulated phosphoprotein (VASP) assay at three time points (before PCI, at hospital discharge and at one month after PCI), with HPR defined as >50% PR index in 1,042 patients treated with aspirin and clopidogrel for one year after PCI. Patients with DM and an SS ¡Ý15 had the highest MACE rate between one month and one year, further increased by the presence of HPR (16.4%). On the other hand, among all patients with an SS

Original languageEnglish
Pages (from-to)312-318
Number of pages7
JournalEuroIntervention
Volume12
Issue number3
DOIs
Publication statusPublished - Jun 1 2016

Keywords

  • Acute coronary syndromes
  • Clopidogrel
  • Diabetes
  • SYNTAX score

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    De Servi, S., Crimi, G., Calabrò, P., Piscione, F., Cattaneo, M., Maffeo, D., Toso, A., Bartorelli, A., Palmieri, C., De Carlo, M., Capodanno, D., Barozzi, C., Tomasi, L., Riva, D., Angiolillo, D. J., & Palmerini, T. (2016). Relationship between diabetes, platelet reactivity, and the SYNTAX score to one-year clinical outcome in patients with non-ST-segment elevation acute coronary syndrome undergoing percutaneous coronary intervention. EuroIntervention, 12(3), 312-318. https://doi.org/10.4244/EIJV12I3A51