Relationship between diffusion parameters derived from intravoxel incoherent motion MRI and perfusion measured by dynamic contrast-enhanced MRI of soft tissue tumors

Simona Marzi, Linda Stefanetti, Francesca Sperati, Vincenzo Anelli

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Our aim was to evaluate the link between diffusion parameters measured by intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI) and the perfusion metrics obtained with dynamic contrast-enhanced (DCE) MRI in soft tissue tumors (STTs). Twenty-eight patients affected by histopathologically confirmed STT were included in a prospective study. All patients underwent both DCE MRI and IVIM DWI. The perfusion fraction f, diffusion coefficient D and perfusion-related diffusion coefficient D* were estimated using a bi-exponential function to fit the DWI data. DCE MRI was acquired with a temporal resolution of 3-5s. Maps of the initial area under the gadolinium concentration curve (IAUGC), time to peak (TTP) and maximum slope of increase (MSI) were derived using commercial software. The relationships between the DCE MRI and IVIM DWI measurements were assessed by Spearman's test. To exclude false positive results under multiple testing, the false discovery rate (FDR) procedure was applied. The Mann-Whitney test was used to evaluate the differences between all variables in patients with non-myxoid and myxoid STT. No significant relationship was found between IVIM parameters and any DCE MRI parameters. Higher f and D*f values were found in non-myxoid tumors compared with myxoid tumors (p=0.004 and p=0.003, respectively). MSI was significantly higher in non-myxoid tumors than in myxoid tumors (p=0.029). From the visual assessments of single clinical cases, both f and D*f maps were in satisfactory agreement with DCE maps in the extreme cases of an avascular mass and a highly vascularized mass, whereas, for tumors with slight vascularity or with a highly heterogeneous perfusion pattern, this association was not straightforward. Although IVIM DWI was demonstrated to be feasible in STT, our data did not support evident relationships between perfusion-related IVIM parameters and perfusion measured by DCE MRI.

Original languageEnglish
Pages (from-to)6-14
Number of pages9
JournalNMR in Biomedicine
Volume29
Issue number1
DOIs
Publication statusPublished - Jan 1 2016

Fingerprint

Magnetic resonance imaging
Tumors
Perfusion
Tissue
Neoplasms
Imaging techniques
Perfusion Imaging
Exponential functions
Gadolinium
Software
Prospective Studies
Testing

Keywords

  • Diffusion-weighted imaging
  • Dynamic contrast-enhanced MRI
  • Intravoxel incoherent motion imaging
  • Quantitative imaging
  • Soft tissue tumors

ASJC Scopus subject areas

  • Spectroscopy
  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging

Cite this

Relationship between diffusion parameters derived from intravoxel incoherent motion MRI and perfusion measured by dynamic contrast-enhanced MRI of soft tissue tumors. / Marzi, Simona; Stefanetti, Linda; Sperati, Francesca; Anelli, Vincenzo.

In: NMR in Biomedicine, Vol. 29, No. 1, 01.01.2016, p. 6-14.

Research output: Contribution to journalArticle

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