Relationship between DNA replicon size and SCE induction in BALB/c and BALB/Mo mouse lymphocytes

F. Majone; L. Busulini; A. Capozzi; N. Bianco; D. Saggioro; A. G. Levis; F. Bordin

doi:10.1016/0165-7992(89)90062-6

Relationship between DNA replicon size and SCE induction in BALB/c and BALB/Mo mouse lymphocytes

F. Majone, L. Busulini, A. Capozzi, N. Bianco, D. Saggioro, A. G. Levis, F. Bordin

Istituto Oncologico Veneto

Research output: Contribution to journal › Article › peer-review

Abstract

We studied the DNA replicon size in BALB/c and BALB/Mo mouse lymphocytes by the method of bromodeoxyuridine photolysis. After treatment of the BALB/Mo lymphocytes in vitro with mitomycin C, the average DNA replicon size appeared to be significantly smaller than that observed in BALB/c lymphocytes treated similarly. In these conditions as increased susceptibility to SCE induction in BALB/Mo lymphocytes had been observed. In the presence of both mitomycin C and cordycepin (an antiviral drug), both the DNA replicon size and the SCE frequency returned to normal values.

Original language	English
Pages (from-to)	17-20
Number of pages	4
Journal	Mutation Research Letters
Volume	227
Issue number	1
DOIs	https://doi.org/10.1016/0165-7992(89)90062-6
Publication status	Published - 1989

Keywords

Cordycepin
DNA replicons
Mitomycin C
Mouse lymphocytes
Sister-chromatid exchange

ASJC Scopus subject areas

Genetics
Toxicology
Medicine(all)

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10.1016/0165-7992(89)90062-6

Cite this

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title = "Relationship between DNA replicon size and SCE induction in BALB/c and BALB/Mo mouse lymphocytes",

abstract = "We studied the DNA replicon size in BALB/c and BALB/Mo mouse lymphocytes by the method of bromodeoxyuridine photolysis. After treatment of the BALB/Mo lymphocytes in vitro with mitomycin C, the average DNA replicon size appeared to be significantly smaller than that observed in BALB/c lymphocytes treated similarly. In these conditions as increased susceptibility to SCE induction in BALB/Mo lymphocytes had been observed. In the presence of both mitomycin C and cordycepin (an antiviral drug), both the DNA replicon size and the SCE frequency returned to normal values.",

keywords = "Cordycepin, DNA replicons, Mitomycin C, Mouse lymphocytes, Sister-chromatid exchange",

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T1 - Relationship between DNA replicon size and SCE induction in BALB/c and BALB/Mo mouse lymphocytes

AU - Majone, F.

AU - Busulini, L.

AU - Capozzi, A.

AU - Bianco, N.

AU - Saggioro, D.

AU - Levis, A. G.

AU - Bordin, F.

PY - 1989

Y1 - 1989

N2 - We studied the DNA replicon size in BALB/c and BALB/Mo mouse lymphocytes by the method of bromodeoxyuridine photolysis. After treatment of the BALB/Mo lymphocytes in vitro with mitomycin C, the average DNA replicon size appeared to be significantly smaller than that observed in BALB/c lymphocytes treated similarly. In these conditions as increased susceptibility to SCE induction in BALB/Mo lymphocytes had been observed. In the presence of both mitomycin C and cordycepin (an antiviral drug), both the DNA replicon size and the SCE frequency returned to normal values.

AB - We studied the DNA replicon size in BALB/c and BALB/Mo mouse lymphocytes by the method of bromodeoxyuridine photolysis. After treatment of the BALB/Mo lymphocytes in vitro with mitomycin C, the average DNA replicon size appeared to be significantly smaller than that observed in BALB/c lymphocytes treated similarly. In these conditions as increased susceptibility to SCE induction in BALB/Mo lymphocytes had been observed. In the presence of both mitomycin C and cordycepin (an antiviral drug), both the DNA replicon size and the SCE frequency returned to normal values.

KW - Cordycepin

KW - DNA replicons

KW - Mitomycin C

KW - Mouse lymphocytes

KW - Sister-chromatid exchange

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Relationship between DNA replicon size and SCE induction in BALB/c and BALB/Mo mouse lymphocytes

Abstract

Keywords

ASJC Scopus subject areas

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