Abstract
We studied the DNA replicon size in BALB/c and BALB/Mo mouse lymphocytes by the method of bromodeoxyuridine photolysis. After treatment of the BALB/Mo lymphocytes in vitro with mitomycin C, the average DNA replicon size appeared to be significantly smaller than that observed in BALB/c lymphocytes treated similarly. In these conditions as increased susceptibility to SCE induction in BALB/Mo lymphocytes had been observed. In the presence of both mitomycin C and cordycepin (an antiviral drug), both the DNA replicon size and the SCE frequency returned to normal values.
| Original language | English |
|---|---|
| Pages (from-to) | 17-20 |
| Number of pages | 4 |
| Journal | Mutation Research Letters |
| Volume | 227 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 1989 |
Keywords
- Cordycepin
- DNA replicons
- Mitomycin C
- Mouse lymphocytes
- Sister-chromatid exchange
ASJC Scopus subject areas
- Genetics
- Toxicology
- Medicine(all)
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Cite this
Majone, F., Busulini, L., Capozzi, A., Bianco, N., Saggioro, D., Levis, A. G., & Bordin, F. (1989). Relationship between DNA replicon size and SCE induction in BALB/c and BALB/Mo mouse lymphocytes. Mutation Research Letters, 227(1), 17-20. https://doi.org/10.1016/0165-7992(89)90062-6