Relationship between DNA replicon size and SCE induction in BALB/c and BALB/Mo mouse lymphocytes

F. Majone, L. Busulini, A. Capozzi, N. Bianco, D. Saggioro, A. G. Levis, F. Bordin

Research output: Contribution to journalArticle

Abstract

We studied the DNA replicon size in BALB/c and BALB/Mo mouse lymphocytes by the method of bromodeoxyuridine photolysis. After treatment of the BALB/Mo lymphocytes in vitro with mitomycin C, the average DNA replicon size appeared to be significantly smaller than that observed in BALB/c lymphocytes treated similarly. In these conditions as increased susceptibility to SCE induction in BALB/Mo lymphocytes had been observed. In the presence of both mitomycin C and cordycepin (an antiviral drug), both the DNA replicon size and the SCE frequency returned to normal values.

Original languageEnglish
Pages (from-to)17-20
Number of pages4
JournalMutation Research Letters
Volume227
Issue number1
DOIs
Publication statusPublished - 1989

Fingerprint

Replicon
Lymphocytes
DNA
Mitomycin
Photolysis
Bromodeoxyuridine
Antiviral Agents
Reference Values

Keywords

  • Cordycepin
  • DNA replicons
  • Mitomycin C
  • Mouse lymphocytes
  • Sister-chromatid exchange

ASJC Scopus subject areas

  • Genetics
  • Toxicology
  • Medicine(all)

Cite this

Relationship between DNA replicon size and SCE induction in BALB/c and BALB/Mo mouse lymphocytes. / Majone, F.; Busulini, L.; Capozzi, A.; Bianco, N.; Saggioro, D.; Levis, A. G.; Bordin, F.

In: Mutation Research Letters, Vol. 227, No. 1, 1989, p. 17-20.

Research output: Contribution to journalArticle

Majone, F. ; Busulini, L. ; Capozzi, A. ; Bianco, N. ; Saggioro, D. ; Levis, A. G. ; Bordin, F. / Relationship between DNA replicon size and SCE induction in BALB/c and BALB/Mo mouse lymphocytes. In: Mutation Research Letters. 1989 ; Vol. 227, No. 1. pp. 17-20.
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