Relationship between DNA replicon size and SCE induction in BALB/c and BALB/Mo mouse lymphocytes

F. Majone, L. Busulini, A. Capozzi, N. Bianco, D. Saggioro, A. G. Levis, F. Bordin

Research output: Contribution to journalArticle

Abstract

We studied the DNA replicon size in BALB/c and BALB/Mo mouse lymphocytes by the method of bromodeoxyuridine photolysis. After treatment of the BALB/Mo lymphocytes in vitro with mitomycin C, the average DNA replicon size appeared to be significantly smaller than that observed in BALB/c lymphocytes treated similarly. In these conditions as increased susceptibility to SCE induction in BALB/Mo lymphocytes had been observed. In the presence of both mitomycin C and cordycepin (an antiviral drug), both the DNA replicon size and the SCE frequency returned to normal values.

Original languageEnglish
Pages (from-to)17-20
Number of pages4
JournalMutation Research Letters
Volume227
Issue number1
DOIs
Publication statusPublished - 1989

Keywords

  • Cordycepin
  • DNA replicons
  • Mitomycin C
  • Mouse lymphocytes
  • Sister-chromatid exchange

ASJC Scopus subject areas

  • Genetics
  • Toxicology
  • Medicine(all)

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