Abstract
We studied the DNA replicon size in BALB/c and BALB/Mo mouse lymphocytes by the method of bromodeoxyuridine photolysis. After treatment of the BALB/Mo lymphocytes in vitro with mitomycin C, the average DNA replicon size appeared to be significantly smaller than that observed in BALB/c lymphocytes treated similarly. In these conditions as increased susceptibility to SCE induction in BALB/Mo lymphocytes had been observed. In the presence of both mitomycin C and cordycepin (an antiviral drug), both the DNA replicon size and the SCE frequency returned to normal values.
Original language | English |
---|---|
Pages (from-to) | 17-20 |
Number of pages | 4 |
Journal | Mutation Research Letters |
Volume | 227 |
Issue number | 1 |
DOIs | |
Publication status | Published - 1989 |
Keywords
- Cordycepin
- DNA replicons
- Mitomycin C
- Mouse lymphocytes
- Sister-chromatid exchange
ASJC Scopus subject areas
- Genetics
- Toxicology
- Medicine(all)