Abstract
We studied the DNA replicon size in BALB/c and BALB/Mo mouse lymphocytes by the method of bromodeoxyuridine photolysis. After treatment of the BALB/Mo lymphocytes in vitro with mitomycin C, the average DNA replicon size appeared to be significantly smaller than that observed in BALB/c lymphocytes treated similarly. In these conditions as increased susceptibility to SCE induction in BALB/Mo lymphocytes had been observed. In the presence of both mitomycin C and cordycepin (an antiviral drug), both the DNA replicon size and the SCE frequency returned to normal values.
| Original language | English |
|---|---|
| Pages (from-to) | 17-20 |
| Number of pages | 4 |
| Journal | Mutation Research Letters |
| Volume | 227 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 1989 |
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Keywords
- Cordycepin
- DNA replicons
- Mitomycin C
- Mouse lymphocytes
- Sister-chromatid exchange
ASJC Scopus subject areas
- Genetics
- Toxicology
- Medicine(all)
Cite this
Relationship between DNA replicon size and SCE induction in BALB/c and BALB/Mo mouse lymphocytes. / Majone, F.; Busulini, L.; Capozzi, A.; Bianco, N.; Saggioro, D.; Levis, A. G.; Bordin, F.
In: Mutation Research Letters, Vol. 227, No. 1, 1989, p. 17-20.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Relationship between DNA replicon size and SCE induction in BALB/c and BALB/Mo mouse lymphocytes
AU - Majone, F.
AU - Busulini, L.
AU - Capozzi, A.
AU - Bianco, N.
AU - Saggioro, D.
AU - Levis, A. G.
AU - Bordin, F.
PY - 1989
Y1 - 1989
N2 - We studied the DNA replicon size in BALB/c and BALB/Mo mouse lymphocytes by the method of bromodeoxyuridine photolysis. After treatment of the BALB/Mo lymphocytes in vitro with mitomycin C, the average DNA replicon size appeared to be significantly smaller than that observed in BALB/c lymphocytes treated similarly. In these conditions as increased susceptibility to SCE induction in BALB/Mo lymphocytes had been observed. In the presence of both mitomycin C and cordycepin (an antiviral drug), both the DNA replicon size and the SCE frequency returned to normal values.
AB - We studied the DNA replicon size in BALB/c and BALB/Mo mouse lymphocytes by the method of bromodeoxyuridine photolysis. After treatment of the BALB/Mo lymphocytes in vitro with mitomycin C, the average DNA replicon size appeared to be significantly smaller than that observed in BALB/c lymphocytes treated similarly. In these conditions as increased susceptibility to SCE induction in BALB/Mo lymphocytes had been observed. In the presence of both mitomycin C and cordycepin (an antiviral drug), both the DNA replicon size and the SCE frequency returned to normal values.
KW - Cordycepin
KW - DNA replicons
KW - Mitomycin C
KW - Mouse lymphocytes
KW - Sister-chromatid exchange
UR - http://www.scopus.com/inward/record.url?scp=0024422468&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024422468&partnerID=8YFLogxK
U2 - 10.1016/0165-7992(89)90062-6
DO - 10.1016/0165-7992(89)90062-6
M3 - Article
C2 - 2505071
AN - SCOPUS:0024422468
VL - 227
SP - 17
EP - 20
JO - Mutation Research Letters
JF - Mutation Research Letters
SN - 0165-7992
IS - 1
ER -