TY - JOUR
T1 - Relationship between energy expenditure, physical activity and weight loss during CPAP treatment in obese OSA subjects
AU - Bamberga, Michele
AU - Rizzi, Maurizio
AU - Gadaleta, Felice
AU - Grechi, Attilio
AU - Baiardini, Renata
AU - Fanfulla, Francesco
PY - 2015/4/1
Y1 - 2015/4/1
N2 - Background Increased energy expenditure (EE) has been reported in patients with obstructive sleep apnea (OSA). It has been postulated that CPAP treatment may induce weight reduction in obese patients, even if it has not been confirmed by recent studies. In the present study we investigated the effect of OSA on EE and the effect of CPAP on body weight and physical activity. Methods One hundred and seven obese OSA patients and 25 healthy obese volunteers, as control group, matched for age, sex and BMI, were enrolled. The following evaluation was performed only in OSA patients after 6 months of CPAP treatment. Results Baseline total EE was similar in the two groups, but OSA patients showed higher EE during the night, while control group during daytime. In patients, EE correlates with OSA severity, degree of daytime sleepiness or obesity. At follow-up evaluation, BMI and total EE were unchanged. However, daytime EE increased (1066 ± 131.5 vs 1104 ± 133 Kcal/die, p <0.001, respectively) and night EE decreased (694 ± 69 vs 595 ± 73, p <0.0001, respectively). Statistically significant changes in BMI, sleepiness scale, blood gases and EE were found only in patients who were compliant to CPAP. Conclusions Obese OSA patients showed an increased night EE that was normalized only in those patients compliant to CPAP. Body weight and daily physical activity did not change in statistically significant way.
AB - Background Increased energy expenditure (EE) has been reported in patients with obstructive sleep apnea (OSA). It has been postulated that CPAP treatment may induce weight reduction in obese patients, even if it has not been confirmed by recent studies. In the present study we investigated the effect of OSA on EE and the effect of CPAP on body weight and physical activity. Methods One hundred and seven obese OSA patients and 25 healthy obese volunteers, as control group, matched for age, sex and BMI, were enrolled. The following evaluation was performed only in OSA patients after 6 months of CPAP treatment. Results Baseline total EE was similar in the two groups, but OSA patients showed higher EE during the night, while control group during daytime. In patients, EE correlates with OSA severity, degree of daytime sleepiness or obesity. At follow-up evaluation, BMI and total EE were unchanged. However, daytime EE increased (1066 ± 131.5 vs 1104 ± 133 Kcal/die, p <0.001, respectively) and night EE decreased (694 ± 69 vs 595 ± 73, p <0.0001, respectively). Statistically significant changes in BMI, sleepiness scale, blood gases and EE were found only in patients who were compliant to CPAP. Conclusions Obese OSA patients showed an increased night EE that was normalized only in those patients compliant to CPAP. Body weight and daily physical activity did not change in statistically significant way.
KW - CPAP
KW - Energy expenditure
KW - Obesity
KW - Sleep
KW - Sleep apnea
KW - Sleepiness
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U2 - 10.1016/j.rmed.2015.02.010
DO - 10.1016/j.rmed.2015.02.010
M3 - Article
C2 - 25769295
AN - SCOPUS:84925813665
VL - 109
SP - 540
EP - 545
JO - Respiratory Medicine
JF - Respiratory Medicine
SN - 0954-6111
IS - 4
ER -