Relationship between fibrin clot retraction and tumorigenesis in C3H/10T1/2 cells

B. Azzarone, D. Brouty-Boye, A. Macieira-Coelho

Research output: Contribution to journalArticlepeer-review

Abstract

Fibrin clot retraction (FCR) was studied in C3H/10T1/2 murine fibroblasts. These cells were able to induce FCR with high efficiency during resting phase as well as during active growth. C3H/10T1/2 cells which became tumorigenic after X-irradiation lacked FCR activity. Non-tumorigenic revertant clones regained the capacity to induce FCR, while revertants which progressively back-reverted to the neoplastic state showed intermediate FCR activity. These unstable revertants, when again fully tumorigenic, completely lost FCR activity.

Original languageEnglish
Pages (from-to)799-803
Number of pages5
JournalInternational Journal of Cancer
Volume28
Issue number6
Publication statusPublished - 1981

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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