Relationship between fibrin clot retraction and tumorigenesis in C3H/10T1/2 cells

B. Azzarone; D. Brouty-Boye; A. Macieira-Coelho

Relationship between fibrin clot retraction and tumorigenesis in C3H/10T1/2 cells

B. Azzarone, D. Brouty-Boye, A. Macieira-Coelho

Istituto "Giannina Gaslini"

Research output: Contribution to journal › Article › peer-review

Abstract

Fibrin clot retraction (FCR) was studied in C3H/10T1/2 murine fibroblasts. These cells were able to induce FCR with high efficiency during resting phase as well as during active growth. C3H/10T1/2 cells which became tumorigenic after X-irradiation lacked FCR activity. Non-tumorigenic revertant clones regained the capacity to induce FCR, while revertants which progressively back-reverted to the neoplastic state showed intermediate FCR activity. These unstable revertants, when again fully tumorigenic, completely lost FCR activity.

Original language	English
Pages (from-to)	799-803
Number of pages	5
Journal	International Journal of Cancer
Volume	28
Issue number	6
Publication status	Published - 1981

ASJC Scopus subject areas

Cancer Research
Oncology

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abstract = "Fibrin clot retraction (FCR) was studied in C3H/10T1/2 murine fibroblasts. These cells were able to induce FCR with high efficiency during resting phase as well as during active growth. C3H/10T1/2 cells which became tumorigenic after X-irradiation lacked FCR activity. Non-tumorigenic revertant clones regained the capacity to induce FCR, while revertants which progressively back-reverted to the neoplastic state showed intermediate FCR activity. These unstable revertants, when again fully tumorigenic, completely lost FCR activity.",

author = "B. Azzarone and D. Brouty-Boye and A. Macieira-Coelho",

year = "1981",

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AU - Azzarone, B.

AU - Brouty-Boye, D.

AU - Macieira-Coelho, A.

PY - 1981

Y1 - 1981

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AB - Fibrin clot retraction (FCR) was studied in C3H/10T1/2 murine fibroblasts. These cells were able to induce FCR with high efficiency during resting phase as well as during active growth. C3H/10T1/2 cells which became tumorigenic after X-irradiation lacked FCR activity. Non-tumorigenic revertant clones regained the capacity to induce FCR, while revertants which progressively back-reverted to the neoplastic state showed intermediate FCR activity. These unstable revertants, when again fully tumorigenic, completely lost FCR activity.

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Relationship between fibrin clot retraction and tumorigenesis in C3H/10T1/2 cells

Abstract

ASJC Scopus subject areas

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