Relationship between functional loss before hospital admission and mortality in elderly persons with medical illness

Renzo Rozzini, Tony Sabatini, Angela Cassinadri, Stefano Boffelli, Marco Ferri, Piera Barbisoni, Giovanni B. Frisoni, Marco Trabucchi

Research output: Contribution to journalArticle


Objective. This hospital-based prospective study tests the hypothesis that, in a large group of hospitalized elderly patients, those who report functional decline between pre-illness baseline and hospital admission have a higher risk of death. Methods. Nine hundred fifty elderly ambulant patients (F = 69.3%; mean age 78.3 ± 8.5 years) were consecutively admitted to a geriatric ward (Poliambulanza Hospital, Brescia, Italy) during a 15-month period. Number and severity of somatic diseases, Charlson Index score, APACHE II score, level of serum albumin, cognitive status (by Mini-Mental State Examination), and depression score (by Geriatric Depression Scale), were assessed on admission and evaluated as potential prognostic factors. Functional status (by Barthel Index) was assessed by self-report on admission. Preadmission function was also assessed by self-report at the time of admission. Impairment of function due to an acute event is measured as the difference between performances on admission and 2 weeks before the acute event. Six-month survival was the main outcome variable. Results. Factors related to mortality in bivariate analysis were: male sex, age over 80, cancer, congestive heart failure, pulmonary diseases, elevated Charlson Index score, and (independently) dementia (Mini-Mental State Examination <18), APACHE-Acute Physiology Score, albumin level

Original languageEnglish
Pages (from-to)1180-1183
Number of pages4
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Issue number9
Publication statusPublished - Sep 2005

ASJC Scopus subject areas

  • Ageing

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