Relationship between glyco-oxidation, antioxidant status and microalbuminuria in type 2 diabetic patients

F. Piarulli, G. Sartore, A. Ceriello, E. Ragazzi, R. Reitano, L. Nollino, C. Cosma, D. Fedele, A. Lapolla

Research output: Contribution to journalArticlepeer-review

Abstract

Aims/hypothesis: This study examined the relationship, if any, between glucose-induced oxidative stress, antioxidant status and microalbuminuria in patients with type 2 diabetes. Methods: The study involved 99 consecutive type 2 diabetic patients (57 men, 42 women). Patients with persistent microalbuminuria were identified and the following variables evaluated: fasting plasma glucose, HbA1c, malonyldialdehyde (MDA), pentosidine, AGE, the total radical-trapping antioxidant parameter (TRAP), vitamin E, creatinine, estimated GFR and lipid profile. Results: Patients were divided into two groups, i.e. 37 individuals without microalbuminuria (AER 1c 7.97∈±∈1.51 vs 7.39∈±∈1.03%, p∈1c r∈=∈0.33, p∈1c and MDA, but not pentosidine or AGE. Conclusions/interpretation: Our data suggest that microalbuminuria in type 2 diabetic patients might be promoted by an insufficient counter-regulation of the antioxidant system in the event of increased glyco-oxidation/glycation.

Original languageEnglish
Pages (from-to)1419-1425
Number of pages7
JournalDiabetologia
Volume52
Issue number7
DOIs
Publication statusPublished - Jul 2009

Keywords

  • Antioxidant status
  • Glyco-oxidation
  • Microalbuminuria
  • Type 2 diabetes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

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