Aims/hypothesis: This study examined the relationship, if any, between glucose-induced oxidative stress, antioxidant status and microalbuminuria in patients with type 2 diabetes. Methods: The study involved 99 consecutive type 2 diabetic patients (57 men, 42 women). Patients with persistent microalbuminuria were identified and the following variables evaluated: fasting plasma glucose, HbA1c, malonyldialdehyde (MDA), pentosidine, AGE, the total radical-trapping antioxidant parameter (TRAP), vitamin E, creatinine, estimated GFR and lipid profile. Results: Patients were divided into two groups, i.e. 37 individuals without microalbuminuria (AER 1c 7.97∈±∈1.51 vs 7.39∈±∈1.03%, p∈1c r∈=∈0.33, p∈1c and MDA, but not pentosidine or AGE. Conclusions/interpretation: Our data suggest that microalbuminuria in type 2 diabetic patients might be promoted by an insufficient counter-regulation of the antioxidant system in the event of increased glyco-oxidation/glycation.
- Antioxidant status
- Type 2 diabetes
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Internal Medicine