Relationship between glyco-oxidation, antioxidant status and microalbuminuria in type 2 diabetic patients

F. Piarulli, G. Sartore, A. Ceriello, E. Ragazzi, R. Reitano, L. Nollino, C. Cosma, D. Fedele, A. Lapolla

Research output: Contribution to journalArticle

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Abstract

Aims/hypothesis: This study examined the relationship, if any, between glucose-induced oxidative stress, antioxidant status and microalbuminuria in patients with type 2 diabetes. Methods: The study involved 99 consecutive type 2 diabetic patients (57 men, 42 women). Patients with persistent microalbuminuria were identified and the following variables evaluated: fasting plasma glucose, HbA1c, malonyldialdehyde (MDA), pentosidine, AGE, the total radical-trapping antioxidant parameter (TRAP), vitamin E, creatinine, estimated GFR and lipid profile. Results: Patients were divided into two groups, i.e. 37 individuals without microalbuminuria (AER 1c 7.97∈±∈1.51 vs 7.39∈±∈1.03%, p∈1c r∈=∈0.33, p∈1c and MDA, but not pentosidine or AGE. Conclusions/interpretation: Our data suggest that microalbuminuria in type 2 diabetic patients might be promoted by an insufficient counter-regulation of the antioxidant system in the event of increased glyco-oxidation/glycation.

Original languageEnglish
Pages (from-to)1419-1425
Number of pages7
JournalDiabetologia
Volume52
Issue number7
DOIs
Publication statusPublished - Jul 2009

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Antioxidants
Malondialdehyde
Glucose
Vitamin E
Type 2 Diabetes Mellitus
Fasting
Creatinine
Oxidative Stress
Lipids
pentosidine

Keywords

  • Antioxidant status
  • Glyco-oxidation
  • Microalbuminuria
  • Type 2 diabetes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

Cite this

Relationship between glyco-oxidation, antioxidant status and microalbuminuria in type 2 diabetic patients. / Piarulli, F.; Sartore, G.; Ceriello, A.; Ragazzi, E.; Reitano, R.; Nollino, L.; Cosma, C.; Fedele, D.; Lapolla, A.

In: Diabetologia, Vol. 52, No. 7, 07.2009, p. 1419-1425.

Research output: Contribution to journalArticle

Piarulli, F, Sartore, G, Ceriello, A, Ragazzi, E, Reitano, R, Nollino, L, Cosma, C, Fedele, D & Lapolla, A 2009, 'Relationship between glyco-oxidation, antioxidant status and microalbuminuria in type 2 diabetic patients', Diabetologia, vol. 52, no. 7, pp. 1419-1425. https://doi.org/10.1007/s00125-009-1367-y
Piarulli, F. ; Sartore, G. ; Ceriello, A. ; Ragazzi, E. ; Reitano, R. ; Nollino, L. ; Cosma, C. ; Fedele, D. ; Lapolla, A. / Relationship between glyco-oxidation, antioxidant status and microalbuminuria in type 2 diabetic patients. In: Diabetologia. 2009 ; Vol. 52, No. 7. pp. 1419-1425.
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