Relationship between growth hormone/insulin-like growth factor-1 axis integrity and voluntary weight loss after gastric banding surgery for severe obesity

Silvia Savastano, Luigi Angrisani, Carolina Di Somma, Francesca Rota, Maria Cristina Savanelli, Teresa Cascella, Francesco Orio, Gaetano Lombardi, Annamaria Colao

Research output: Contribution to journalArticle

Abstract

Background: The aim of this observational study was to determine, in a retrospective analysis, whether growth hormone (GH) and insulin-like growth factor-1 (IGF-1) at baseline or changes in the GH/IGF-1 axis after laparoscopic adjustable gastric banding (LAGB) is associated with weight loss and body composition changes in severely obese nondiabetic patients. Methods: Weight loss (expressed as percent excess weight loss [EWL%]), anthropometry, body composition by bioelectrical impedance analysis (BIA), serum IGF-1, and GH peak after GH-releasing hormone (GHRH) plus arginine (ARG) test were measured and expressed as standard deviation scores (SDS) of reference values in 104 women and 36 men, age (mean ± SD) 34±11 and 30.2±11 years, and BMI 44±5.7 and 39±3.2, respectively, before and 6 months after LAGB. Results: After LAGB, 25% of women and 22.5% of men had GH deficiency, while 30.8% of women and 33.3% of men had IGF-1 deficiency or insufficiency. The median EWL was 36.8% in women and 40.0% in men. In both genders, percent decrease of waist circumference, EWL, and fat mass (FM) and percent increase of fat-free mass (FFM) was greater in patients with normal GH secretion and IGF-1 levels. The GH peak after GHRH + ARG, IGF-1 levels, and IGF-1 SDS were inversely correlated with EWL% (r=-0.50, r=-0.53, and r=-0.42, respectively; p

Original languageEnglish
Pages (from-to)211-220
Number of pages10
JournalObesity Surgery
Volume20
Issue number2
DOIs
Publication statusPublished - Feb 2010

Keywords

  • Fat mass
  • Fat-free mass
  • GH
  • IGF-I
  • LAGB
  • Obesity

ASJC Scopus subject areas

  • Surgery
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

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