TY - JOUR
T1 - Relationship between growth hormone/insulin-like growth factor-1 axis integrity and voluntary weight loss after gastric banding surgery for severe obesity
AU - Savastano, Silvia
AU - Angrisani, Luigi
AU - Di Somma, Carolina
AU - Rota, Francesca
AU - Savanelli, Maria Cristina
AU - Cascella, Teresa
AU - Orio, Francesco
AU - Lombardi, Gaetano
AU - Colao, Annamaria
PY - 2010/2
Y1 - 2010/2
N2 - Background: The aim of this observational study was to determine, in a retrospective analysis, whether growth hormone (GH) and insulin-like growth factor-1 (IGF-1) at baseline or changes in the GH/IGF-1 axis after laparoscopic adjustable gastric banding (LAGB) is associated with weight loss and body composition changes in severely obese nondiabetic patients. Methods: Weight loss (expressed as percent excess weight loss [EWL%]), anthropometry, body composition by bioelectrical impedance analysis (BIA), serum IGF-1, and GH peak after GH-releasing hormone (GHRH) plus arginine (ARG) test were measured and expressed as standard deviation scores (SDS) of reference values in 104 women and 36 men, age (mean ± SD) 34±11 and 30.2±11 years, and BMI 44±5.7 and 39±3.2, respectively, before and 6 months after LAGB. Results: After LAGB, 25% of women and 22.5% of men had GH deficiency, while 30.8% of women and 33.3% of men had IGF-1 deficiency or insufficiency. The median EWL was 36.8% in women and 40.0% in men. In both genders, percent decrease of waist circumference, EWL, and fat mass (FM) and percent increase of fat-free mass (FFM) was greater in patients with normal GH secretion and IGF-1 levels. The GH peak after GHRH + ARG, IGF-1 levels, and IGF-1 SDS were inversely correlated with EWL% (r=-0.50, r=-0.53, and r=-0.42, respectively; p
AB - Background: The aim of this observational study was to determine, in a retrospective analysis, whether growth hormone (GH) and insulin-like growth factor-1 (IGF-1) at baseline or changes in the GH/IGF-1 axis after laparoscopic adjustable gastric banding (LAGB) is associated with weight loss and body composition changes in severely obese nondiabetic patients. Methods: Weight loss (expressed as percent excess weight loss [EWL%]), anthropometry, body composition by bioelectrical impedance analysis (BIA), serum IGF-1, and GH peak after GH-releasing hormone (GHRH) plus arginine (ARG) test were measured and expressed as standard deviation scores (SDS) of reference values in 104 women and 36 men, age (mean ± SD) 34±11 and 30.2±11 years, and BMI 44±5.7 and 39±3.2, respectively, before and 6 months after LAGB. Results: After LAGB, 25% of women and 22.5% of men had GH deficiency, while 30.8% of women and 33.3% of men had IGF-1 deficiency or insufficiency. The median EWL was 36.8% in women and 40.0% in men. In both genders, percent decrease of waist circumference, EWL, and fat mass (FM) and percent increase of fat-free mass (FFM) was greater in patients with normal GH secretion and IGF-1 levels. The GH peak after GHRH + ARG, IGF-1 levels, and IGF-1 SDS were inversely correlated with EWL% (r=-0.50, r=-0.53, and r=-0.42, respectively; p
KW - Fat mass
KW - Fat-free mass
KW - GH
KW - IGF-I
KW - LAGB
KW - Obesity
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U2 - 10.1007/s11695-009-9926-3
DO - 10.1007/s11695-009-9926-3
M3 - Article
C2 - 19636643
AN - SCOPUS:77949271602
VL - 20
SP - 211
EP - 220
JO - Obesity Surgery
JF - Obesity Surgery
SN - 0960-8923
IS - 2
ER -