Relationship between health-related quality of life measures and high HIV viral load in HIV-infected triple-class-experienced patients

Raffaella Bucciardini, Katherina Pugliese, Liliana Weimer, Massimiliano Digregorio, Vincenzo Fragola, Mariagrazia Mancini, Zaira Maroccia, Nicoletta Ladisa, Daniela Francisci, Rita Bellagamba, Anna Degli Antoni, Giovanni Guaraldi, Oscar Cirioni, Francesco Ortu, Giustino Parruti, Marco Mannazzu, Raffaella Libertone, Stefania Donnini, Marco Floridia

Research output: Contribution to journalArticle

Abstract

Background: Health-related quality of life (HRQoL) has been recognized as a central measure of the overall health status in HIV patients. With the availability of different highly effective drug combinations, maximizing quality-adjusted survival has become a major target of HIV treatment. Although the association of HIV RNA and CD4 cell count with clinical HIV progression has been well established, the relation between these markers and HRQoL measures is still unclear. Method: This cross-sectional study investigated the relationship linking HIV RNA and CD4 to HRQoL measures in 181 triple-class-experienced patients with advanced HIV disease. The instrument used was the ISSQoL, a self-administered and HIV-specific HRQoL questionnaire. Results: Data showed no correlation between HRQoL measures and CD4 counts. Higher HIV RNA levels were, however, associated with poor HRQoL scores in 3 out of 9 scales of social functioning, depression and anxiety, and satisfaction with quality of life. In multivariable analyses, only the satisfaction with quality of life mean score remained significantly lower for the HIV RNA > 100,000 copies/mL group compared to the HIV RNA 50 to 10,000 copies/mL group. Conclusions: Although other determinants of HRQoL in people with HIV should also be considered, this finding suggests a negative impact of high viral load on perceived HRQoL that adds to other described determinants of lower quality of life in people with HIV, such as lower social support and self-reported symptoms.

Original languageEnglish
Pages (from-to)176-183
Number of pages8
JournalHIV Clinical Trials
Volume15
Issue number4
DOIs
Publication statusPublished - Jan 1 2014

Fingerprint

Viral Load
Quality of Life
HIV
RNA
CD4 Lymphocyte Count
Drug Combinations
Social Support
Health Status
Anxiety
Cross-Sectional Studies
Depression

Keywords

  • HIV/AIDS
  • HRQoL
  • viral load

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

Cite this

Bucciardini, R., Pugliese, K., Weimer, L., Digregorio, M., Fragola, V., Mancini, M., ... Floridia, M. (2014). Relationship between health-related quality of life measures and high HIV viral load in HIV-infected triple-class-experienced patients. HIV Clinical Trials, 15(4), 176-183. https://doi.org/10.1310/hct1504-176

Relationship between health-related quality of life measures and high HIV viral load in HIV-infected triple-class-experienced patients. / Bucciardini, Raffaella; Pugliese, Katherina; Weimer, Liliana; Digregorio, Massimiliano; Fragola, Vincenzo; Mancini, Mariagrazia; Maroccia, Zaira; Ladisa, Nicoletta; Francisci, Daniela; Bellagamba, Rita; Degli Antoni, Anna; Guaraldi, Giovanni; Cirioni, Oscar; Ortu, Francesco; Parruti, Giustino; Mannazzu, Marco; Libertone, Raffaella; Donnini, Stefania; Floridia, Marco.

In: HIV Clinical Trials, Vol. 15, No. 4, 01.01.2014, p. 176-183.

Research output: Contribution to journalArticle

Bucciardini, R, Pugliese, K, Weimer, L, Digregorio, M, Fragola, V, Mancini, M, Maroccia, Z, Ladisa, N, Francisci, D, Bellagamba, R, Degli Antoni, A, Guaraldi, G, Cirioni, O, Ortu, F, Parruti, G, Mannazzu, M, Libertone, R, Donnini, S & Floridia, M 2014, 'Relationship between health-related quality of life measures and high HIV viral load in HIV-infected triple-class-experienced patients', HIV Clinical Trials, vol. 15, no. 4, pp. 176-183. https://doi.org/10.1310/hct1504-176
Bucciardini, Raffaella ; Pugliese, Katherina ; Weimer, Liliana ; Digregorio, Massimiliano ; Fragola, Vincenzo ; Mancini, Mariagrazia ; Maroccia, Zaira ; Ladisa, Nicoletta ; Francisci, Daniela ; Bellagamba, Rita ; Degli Antoni, Anna ; Guaraldi, Giovanni ; Cirioni, Oscar ; Ortu, Francesco ; Parruti, Giustino ; Mannazzu, Marco ; Libertone, Raffaella ; Donnini, Stefania ; Floridia, Marco. / Relationship between health-related quality of life measures and high HIV viral load in HIV-infected triple-class-experienced patients. In: HIV Clinical Trials. 2014 ; Vol. 15, No. 4. pp. 176-183.
@article{cc26cd3c2006473c988424e3743b1a7d,
title = "Relationship between health-related quality of life measures and high HIV viral load in HIV-infected triple-class-experienced patients",
abstract = "Background: Health-related quality of life (HRQoL) has been recognized as a central measure of the overall health status in HIV patients. With the availability of different highly effective drug combinations, maximizing quality-adjusted survival has become a major target of HIV treatment. Although the association of HIV RNA and CD4 cell count with clinical HIV progression has been well established, the relation between these markers and HRQoL measures is still unclear. Method: This cross-sectional study investigated the relationship linking HIV RNA and CD4 to HRQoL measures in 181 triple-class-experienced patients with advanced HIV disease. The instrument used was the ISSQoL, a self-administered and HIV-specific HRQoL questionnaire. Results: Data showed no correlation between HRQoL measures and CD4 counts. Higher HIV RNA levels were, however, associated with poor HRQoL scores in 3 out of 9 scales of social functioning, depression and anxiety, and satisfaction with quality of life. In multivariable analyses, only the satisfaction with quality of life mean score remained significantly lower for the HIV RNA > 100,000 copies/mL group compared to the HIV RNA 50 to 10,000 copies/mL group. Conclusions: Although other determinants of HRQoL in people with HIV should also be considered, this finding suggests a negative impact of high viral load on perceived HRQoL that adds to other described determinants of lower quality of life in people with HIV, such as lower social support and self-reported symptoms.",
keywords = "HIV/AIDS, HRQoL, viral load",
author = "Raffaella Bucciardini and Katherina Pugliese and Liliana Weimer and Massimiliano Digregorio and Vincenzo Fragola and Mariagrazia Mancini and Zaira Maroccia and Nicoletta Ladisa and Daniela Francisci and Rita Bellagamba and {Degli Antoni}, Anna and Giovanni Guaraldi and Oscar Cirioni and Francesco Ortu and Giustino Parruti and Marco Mannazzu and Raffaella Libertone and Stefania Donnini and Marco Floridia",
year = "2014",
month = "1",
day = "1",
doi = "10.1310/hct1504-176",
language = "English",
volume = "15",
pages = "176--183",
journal = "HIV Clinical Trials",
issn = "1528-4336",
publisher = "Taylor and Francis Ltd.",
number = "4",

}

TY - JOUR

T1 - Relationship between health-related quality of life measures and high HIV viral load in HIV-infected triple-class-experienced patients

AU - Bucciardini, Raffaella

AU - Pugliese, Katherina

AU - Weimer, Liliana

AU - Digregorio, Massimiliano

AU - Fragola, Vincenzo

AU - Mancini, Mariagrazia

AU - Maroccia, Zaira

AU - Ladisa, Nicoletta

AU - Francisci, Daniela

AU - Bellagamba, Rita

AU - Degli Antoni, Anna

AU - Guaraldi, Giovanni

AU - Cirioni, Oscar

AU - Ortu, Francesco

AU - Parruti, Giustino

AU - Mannazzu, Marco

AU - Libertone, Raffaella

AU - Donnini, Stefania

AU - Floridia, Marco

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Background: Health-related quality of life (HRQoL) has been recognized as a central measure of the overall health status in HIV patients. With the availability of different highly effective drug combinations, maximizing quality-adjusted survival has become a major target of HIV treatment. Although the association of HIV RNA and CD4 cell count with clinical HIV progression has been well established, the relation between these markers and HRQoL measures is still unclear. Method: This cross-sectional study investigated the relationship linking HIV RNA and CD4 to HRQoL measures in 181 triple-class-experienced patients with advanced HIV disease. The instrument used was the ISSQoL, a self-administered and HIV-specific HRQoL questionnaire. Results: Data showed no correlation between HRQoL measures and CD4 counts. Higher HIV RNA levels were, however, associated with poor HRQoL scores in 3 out of 9 scales of social functioning, depression and anxiety, and satisfaction with quality of life. In multivariable analyses, only the satisfaction with quality of life mean score remained significantly lower for the HIV RNA > 100,000 copies/mL group compared to the HIV RNA 50 to 10,000 copies/mL group. Conclusions: Although other determinants of HRQoL in people with HIV should also be considered, this finding suggests a negative impact of high viral load on perceived HRQoL that adds to other described determinants of lower quality of life in people with HIV, such as lower social support and self-reported symptoms.

AB - Background: Health-related quality of life (HRQoL) has been recognized as a central measure of the overall health status in HIV patients. With the availability of different highly effective drug combinations, maximizing quality-adjusted survival has become a major target of HIV treatment. Although the association of HIV RNA and CD4 cell count with clinical HIV progression has been well established, the relation between these markers and HRQoL measures is still unclear. Method: This cross-sectional study investigated the relationship linking HIV RNA and CD4 to HRQoL measures in 181 triple-class-experienced patients with advanced HIV disease. The instrument used was the ISSQoL, a self-administered and HIV-specific HRQoL questionnaire. Results: Data showed no correlation between HRQoL measures and CD4 counts. Higher HIV RNA levels were, however, associated with poor HRQoL scores in 3 out of 9 scales of social functioning, depression and anxiety, and satisfaction with quality of life. In multivariable analyses, only the satisfaction with quality of life mean score remained significantly lower for the HIV RNA > 100,000 copies/mL group compared to the HIV RNA 50 to 10,000 copies/mL group. Conclusions: Although other determinants of HRQoL in people with HIV should also be considered, this finding suggests a negative impact of high viral load on perceived HRQoL that adds to other described determinants of lower quality of life in people with HIV, such as lower social support and self-reported symptoms.

KW - HIV/AIDS

KW - HRQoL

KW - viral load

UR - http://www.scopus.com/inward/record.url?scp=84906717485&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84906717485&partnerID=8YFLogxK

U2 - 10.1310/hct1504-176

DO - 10.1310/hct1504-176

M3 - Article

C2 - 25143026

AN - SCOPUS:84906717485

VL - 15

SP - 176

EP - 183

JO - HIV Clinical Trials

JF - HIV Clinical Trials

SN - 1528-4336

IS - 4

ER -