Relationship between infarct size and severity measured by gated SPECT and long-term left ventricular remodelling after acute myocardial infarction

Valentina Berti, Roberto Sciagrà, Wanda Acampa, Francesca Ricci, Giampaolo Cerisano, Rosj Gallicchio, Carlo Vigorito, Alberto Pupi, Alberto Cuocolo

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: After acute myocardial infarction (AMI), left ventricular (LV) remodelling may occur despite successful reperfusion. This study aimed to investigate by gated single photon emission computed tomography (SPECT) the long-term evolution of myocardial perfusion and LV function after AMI and to identify the predictors of LV remodelling. Methods: Sixty-eight AMI patients successfully treated by primary percutaneous coronary intervention underwent 99mTc-sestamibi gated SPECT at 1 month (baseline) and over 6-month follow-up after the acute event. LV remodelling was defined as 20% increase in LV end-diastolic volume at follow-up. Results: At baseline, patients with remodelling (n=14) showed larger (infarct size 29.3±7.8%) and more transmural (infarct severity 0.28±0.10) infarctions, and reduced LV ejection fraction (35.4±5.6%), but similar LV volume indexes, compared to patients without remodelling (n=54) (infarct size 20.8±14.4%, p

Original languageEnglish
Pages (from-to)1124-1131
Number of pages8
JournalEuropean Journal of Nuclear Medicine and Molecular Imaging
Volume38
Issue number6
DOIs
Publication statusPublished - Jun 2011

Keywords

  • Acute myocardial infarction
  • Left ventricular function
  • Myocardial perfusion
  • Ventricular remodelling

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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