Relationship between inflammatory parameters and cardiovascular and lifestyle factors in the Mugello study oldest old

Raffaello Molino Lova, Cristina Vassalle, Elisabetta Masini, Silvia Del Ry, Manuela Cabiati, Guido Pasquini, Claudio Macchi

Research output: Contribution to journalArticlepeer-review

Abstract

Aim: To explore possible inter-relationships of various biomarkers of inflammation and lifestyle and other cardiovascular risk factors (age, gender, smoking history, hypertension, Type 2 diabetes, dyslipidemia, alteration of circadian rhythms, body mass index, calf circumference, thigh circumference, abdominal circumference) in the Mugello study oldest old. Methods: In 399 noninstitutionalized nonagenarians (291 women), whole blood cells, mean platelet volume, C-reactive protein, uric acid, gamma-glutamyl transferase were assessed. Results: Aging resulted as the only independent determinant for uric acid (<0.05), and abdominal circumference for C-reactive protein. Female gender (<0.01), and thigh circumference (<0.05) remained as determinants for mean platelet volume, age (<0.01), and male gender (<0.01) for gamma-glutamyl transferase, and Type 2 diabetes (≤0.01) and alteration of circadian rhythms (<0.05) for whole blood cells. Conclusion: Several inflammatory parameters remain associated with adverse lifestyle and cardiovascular risk factors even among nonagenarians.

Original languageEnglish
Pages (from-to)1115-1124
Number of pages10
JournalBiomarkers in Medicine
Volume12
Issue number10
DOIs
Publication statusPublished - Oct 1 2018

Keywords

  • cardiovascular risk factors
  • inflammation
  • lifestyle
  • nonagenarians
  • oldest old
  • oxidative stress

ASJC Scopus subject areas

  • Drug Discovery
  • Clinical Biochemistry
  • Biochemistry, medical

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