TY - JOUR
T1 - Relationship between inflammatory parameters and cardiovascular and lifestyle factors in the Mugello study oldest old
AU - Molino Lova, Raffaello
AU - Vassalle, Cristina
AU - Masini, Elisabetta
AU - Del Ry, Silvia
AU - Cabiati, Manuela
AU - Pasquini, Guido
AU - Macchi, Claudio
PY - 2018/10/1
Y1 - 2018/10/1
N2 - Aim: To explore possible inter-relationships of various biomarkers of inflammation and lifestyle and other cardiovascular risk factors (age, gender, smoking history, hypertension, Type 2 diabetes, dyslipidemia, alteration of circadian rhythms, body mass index, calf circumference, thigh circumference, abdominal circumference) in the Mugello study oldest old. Methods: In 399 noninstitutionalized nonagenarians (291 women), whole blood cells, mean platelet volume, C-reactive protein, uric acid, gamma-glutamyl transferase were assessed. Results: Aging resulted as the only independent determinant for uric acid (<0.05), and abdominal circumference for C-reactive protein. Female gender (<0.01), and thigh circumference (<0.05) remained as determinants for mean platelet volume, age (<0.01), and male gender (<0.01) for gamma-glutamyl transferase, and Type 2 diabetes (≤0.01) and alteration of circadian rhythms (<0.05) for whole blood cells. Conclusion: Several inflammatory parameters remain associated with adverse lifestyle and cardiovascular risk factors even among nonagenarians.
AB - Aim: To explore possible inter-relationships of various biomarkers of inflammation and lifestyle and other cardiovascular risk factors (age, gender, smoking history, hypertension, Type 2 diabetes, dyslipidemia, alteration of circadian rhythms, body mass index, calf circumference, thigh circumference, abdominal circumference) in the Mugello study oldest old. Methods: In 399 noninstitutionalized nonagenarians (291 women), whole blood cells, mean platelet volume, C-reactive protein, uric acid, gamma-glutamyl transferase were assessed. Results: Aging resulted as the only independent determinant for uric acid (<0.05), and abdominal circumference for C-reactive protein. Female gender (<0.01), and thigh circumference (<0.05) remained as determinants for mean platelet volume, age (<0.01), and male gender (<0.01) for gamma-glutamyl transferase, and Type 2 diabetes (≤0.01) and alteration of circadian rhythms (<0.05) for whole blood cells. Conclusion: Several inflammatory parameters remain associated with adverse lifestyle and cardiovascular risk factors even among nonagenarians.
KW - cardiovascular risk factors
KW - inflammation
KW - lifestyle
KW - nonagenarians
KW - oldest old
KW - oxidative stress
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U2 - 10.2217/bmm-2017-0441
DO - 10.2217/bmm-2017-0441
M3 - Article
C2 - 30203672
AN - SCOPUS:85054454215
VL - 12
SP - 1115
EP - 1124
JO - Biomarkers in Medicine
JF - Biomarkers in Medicine
SN - 1752-0363
IS - 10
ER -