Corticosterone added in vitro accumulates in the epididymal adipose tissue in an amount proportional to its concentration in the medium, and inversely proportional to the rate of lipolysis. This effect requires the presence of albumin in the medium. Determinations of partition coefficients between buffer phosphate and oil indicate that corticosterone is retained in the water phase when albumin is added. The simultaneous presence of albumin and FFA further decreases the entry of corticosterone in the oil phase. These results are interpreted in terms of the degree of binding of corticosterone to albumin.
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