Relationship between lipoprotein(a) levels, oxidative stress, and blood pressure levels in patients with essential hypertension

R. Antonicelli, R. Testa, A. R. Bonfigli, C. Sirolla, C. Pieri, M. Marra, S. M. Marcovina

Research output: Contribution to journalArticlepeer-review

Abstract

High plasma levels of lipoprotein(a) [Lp(a)] are considered a risk factor for the development of coronary artery disease. In vitro experiments have shown that oxidized Lp(a) is able to impair the arterial endothelium-dependent dilation, thus suggesting a possible role of Lp(a) in the genesis of essential hypertension. The aim of our work was to investigate the correlation of blood pressure levels with plasma Lp(a) concentration, apo(a) isoform size, and peroxidative stress in patients with essential hypertension. The study was performed in 54 untreated hypertensive patients whose blood pressure was monitored for 24 h by ambulatory blood pressure monitoring. Lp(a) concentration was measured by a double monoclonal antibody-based enzyme immunoassay demonstrated to be insensitive to apo(a) size heterogeneity. Apo(a) isoforms were determined by a high-resolution SDS-agarose gel electrophoresis followed by immunoblotting. A significant correlation was found between Lp(a) levels and the night-time systolic and diastolic pressures (r=0.32, P

Original languageEnglish
Pages (from-to)145-150
Number of pages6
JournalClinical and Experimental Medicine
Volume1
Issue number3
Publication statusPublished - 2001

Keywords

  • Blood pressure
  • Coronary artery disease
  • Lipoprotein(a)
  • Peroxidative stress

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Clinical Biochemistry

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