Relationship between low levels of high-density lipoprotein cholesterol and dementia in the elderly. the inchianti study

G. Zuliani, M. Cavalieri, M. Galvani, S. Volpato, A. Cherubini, S. Bandinelli, A. M. Corsi, F. Lauretani, J. M. Guralnik, R. Fellin, L. Ferrucci

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Abstract

Background.To evaluate the association between plasma lipid fractions and the prevalence of dementia in a large sample of Italian older individuals.Methods.A total of 1051 older community-dwelling individuals (age ≥65 years), enrolled in the InChianti study, were included. Diagnosis of dementia was established at baseline and at the 3-year follow-up using Diagnostic and Statistical Manual of Mental Disorder (Fourth Edition) criteria. Plasma lipids were measured by standardized methods at baseline and after 3 years.Results.At baseline, 61 individuals (5.8%) were affected by dementia. Demented individuals showed significantly lower total cholesterol (TC), nonhigh-density lipoprotein cholesterol, and high-density lipoprotein cholesterol (HDL-C) levels compared with controls; no differences were found in triglycerides (TG) and lipoprotein (a) levels. Of the 819 subjects reevaluated at the 3-year follow-up, 81 (9.9%) received a new diagnosis of dementia. Again, demented subjects were characterized by significantly lower TC, non-HDL-C, and HDL-C levels compared with controls, thus confirming the baseline findings. At multivariate logistic regression analysis, HDL-C levels (odds ratio: 0.96, 95% confidence interval: 0.93-0.99), but not TG and non-HDL-C, were associated with dementia independent of important confounders including age, gender, apo E phenotype, stroke, weight loss, interleukin 6 levels, and ankle-brachial index.Conclusions.Among community-dwelling older people, individuals affected by dementia showed significantly lower TC, non-HDL-C, and HDL-C levels; however, at multivariate analysis, only HDL-C was associated with dementia. Our results suggest the existence of an independent relationship between dementia and low HDL-C levels.

Original languageEnglish
Pages (from-to)559-564
Number of pages6
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume65 A
Issue number5
DOIs
Publication statusPublished - May 2010

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HDL Cholesterol
Dementia
Independent Living
Cholesterol
Triglycerides
Lipids
Ankle Brachial Index
Lipoprotein(a)
Apolipoproteins E
Diagnostic and Statistical Manual of Mental Disorders
LDL Cholesterol
Weight Loss
Interleukin-6
Multivariate Analysis
Logistic Models
Stroke
Odds Ratio
Regression Analysis
Confidence Intervals
Phenotype

Keywords

  • Dementia
  • Elderly
  • Lipids

ASJC Scopus subject areas

  • Ageing
  • Geriatrics and Gerontology
  • Medicine(all)

Cite this

Relationship between low levels of high-density lipoprotein cholesterol and dementia in the elderly. the inchianti study. / Zuliani, G.; Cavalieri, M.; Galvani, M.; Volpato, S.; Cherubini, A.; Bandinelli, S.; Corsi, A. M.; Lauretani, F.; Guralnik, J. M.; Fellin, R.; Ferrucci, L.

In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences, Vol. 65 A, No. 5, 05.2010, p. 559-564.

Research output: Contribution to journalArticle

Zuliani, G, Cavalieri, M, Galvani, M, Volpato, S, Cherubini, A, Bandinelli, S, Corsi, AM, Lauretani, F, Guralnik, JM, Fellin, R & Ferrucci, L 2010, 'Relationship between low levels of high-density lipoprotein cholesterol and dementia in the elderly. the inchianti study', Journals of Gerontology - Series A Biological Sciences and Medical Sciences, vol. 65 A, no. 5, pp. 559-564. https://doi.org/10.1093/gerona/glq026
Zuliani, G. ; Cavalieri, M. ; Galvani, M. ; Volpato, S. ; Cherubini, A. ; Bandinelli, S. ; Corsi, A. M. ; Lauretani, F. ; Guralnik, J. M. ; Fellin, R. ; Ferrucci, L. / Relationship between low levels of high-density lipoprotein cholesterol and dementia in the elderly. the inchianti study. In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 2010 ; Vol. 65 A, No. 5. pp. 559-564.
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abstract = "Background.To evaluate the association between plasma lipid fractions and the prevalence of dementia in a large sample of Italian older individuals.Methods.A total of 1051 older community-dwelling individuals (age ≥65 years), enrolled in the InChianti study, were included. Diagnosis of dementia was established at baseline and at the 3-year follow-up using Diagnostic and Statistical Manual of Mental Disorder (Fourth Edition) criteria. Plasma lipids were measured by standardized methods at baseline and after 3 years.Results.At baseline, 61 individuals (5.8{\%}) were affected by dementia. Demented individuals showed significantly lower total cholesterol (TC), nonhigh-density lipoprotein cholesterol, and high-density lipoprotein cholesterol (HDL-C) levels compared with controls; no differences were found in triglycerides (TG) and lipoprotein (a) levels. Of the 819 subjects reevaluated at the 3-year follow-up, 81 (9.9{\%}) received a new diagnosis of dementia. Again, demented subjects were characterized by significantly lower TC, non-HDL-C, and HDL-C levels compared with controls, thus confirming the baseline findings. At multivariate logistic regression analysis, HDL-C levels (odds ratio: 0.96, 95{\%} confidence interval: 0.93-0.99), but not TG and non-HDL-C, were associated with dementia independent of important confounders including age, gender, apo E phenotype, stroke, weight loss, interleukin 6 levels, and ankle-brachial index.Conclusions.Among community-dwelling older people, individuals affected by dementia showed significantly lower TC, non-HDL-C, and HDL-C levels; however, at multivariate analysis, only HDL-C was associated with dementia. Our results suggest the existence of an independent relationship between dementia and low HDL-C levels.",
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AU - Zuliani, G.

AU - Cavalieri, M.

AU - Galvani, M.

AU - Volpato, S.

AU - Cherubini, A.

AU - Bandinelli, S.

AU - Corsi, A. M.

AU - Lauretani, F.

AU - Guralnik, J. M.

AU - Fellin, R.

AU - Ferrucci, L.

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N2 - Background.To evaluate the association between plasma lipid fractions and the prevalence of dementia in a large sample of Italian older individuals.Methods.A total of 1051 older community-dwelling individuals (age ≥65 years), enrolled in the InChianti study, were included. Diagnosis of dementia was established at baseline and at the 3-year follow-up using Diagnostic and Statistical Manual of Mental Disorder (Fourth Edition) criteria. Plasma lipids were measured by standardized methods at baseline and after 3 years.Results.At baseline, 61 individuals (5.8%) were affected by dementia. Demented individuals showed significantly lower total cholesterol (TC), nonhigh-density lipoprotein cholesterol, and high-density lipoprotein cholesterol (HDL-C) levels compared with controls; no differences were found in triglycerides (TG) and lipoprotein (a) levels. Of the 819 subjects reevaluated at the 3-year follow-up, 81 (9.9%) received a new diagnosis of dementia. Again, demented subjects were characterized by significantly lower TC, non-HDL-C, and HDL-C levels compared with controls, thus confirming the baseline findings. At multivariate logistic regression analysis, HDL-C levels (odds ratio: 0.96, 95% confidence interval: 0.93-0.99), but not TG and non-HDL-C, were associated with dementia independent of important confounders including age, gender, apo E phenotype, stroke, weight loss, interleukin 6 levels, and ankle-brachial index.Conclusions.Among community-dwelling older people, individuals affected by dementia showed significantly lower TC, non-HDL-C, and HDL-C levels; however, at multivariate analysis, only HDL-C was associated with dementia. Our results suggest the existence of an independent relationship between dementia and low HDL-C levels.

AB - Background.To evaluate the association between plasma lipid fractions and the prevalence of dementia in a large sample of Italian older individuals.Methods.A total of 1051 older community-dwelling individuals (age ≥65 years), enrolled in the InChianti study, were included. Diagnosis of dementia was established at baseline and at the 3-year follow-up using Diagnostic and Statistical Manual of Mental Disorder (Fourth Edition) criteria. Plasma lipids were measured by standardized methods at baseline and after 3 years.Results.At baseline, 61 individuals (5.8%) were affected by dementia. Demented individuals showed significantly lower total cholesterol (TC), nonhigh-density lipoprotein cholesterol, and high-density lipoprotein cholesterol (HDL-C) levels compared with controls; no differences were found in triglycerides (TG) and lipoprotein (a) levels. Of the 819 subjects reevaluated at the 3-year follow-up, 81 (9.9%) received a new diagnosis of dementia. Again, demented subjects were characterized by significantly lower TC, non-HDL-C, and HDL-C levels compared with controls, thus confirming the baseline findings. At multivariate logistic regression analysis, HDL-C levels (odds ratio: 0.96, 95% confidence interval: 0.93-0.99), but not TG and non-HDL-C, were associated with dementia independent of important confounders including age, gender, apo E phenotype, stroke, weight loss, interleukin 6 levels, and ankle-brachial index.Conclusions.Among community-dwelling older people, individuals affected by dementia showed significantly lower TC, non-HDL-C, and HDL-C levels; however, at multivariate analysis, only HDL-C was associated with dementia. Our results suggest the existence of an independent relationship between dementia and low HDL-C levels.

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