Relationship between motor function of the proximal stomach and transient lower oesophageal sphincter relaxation after morphine

R. Penagini, M. Allocca, P. Cantù, M. Mangano, D. Savojardo, S. Carmagnola, P. A. Bianchi

Research output: Contribution to journalArticle


Background: Morphine reduces the rate of transient lower oesophageal sphincter (LOS) relaxations but its site of action is presently unknown. There are no data available concerning its motor effects on the proximal stomach, an important site for triggering transient LOS relaxations. Aim: To evaluate the effect of morphine on the rate of transient LOS relaxations and motor function of the proximal stomach. Subjects and methods: In 19 healthy subjects, concurrent transient LOS relaxations with a sleeve sensor and motor function of the proximal stomach with a bag connected to an electronic barostat were recorded during pressure controlled (n = 9) and volume controlled (n = 10) gastric distensions after intravenous administration of placebo and morphine 100 μg/kg. Results: During pressure controlled distensions, intrabag volume was markedly decreased by morphine (median 189 ml (interquartile range 101-448) v 404 (265-868) after placebo; p

Original languageEnglish
Pages (from-to)1227-1231
Number of pages5
Issue number9
Publication statusPublished - Sep 2004


ASJC Scopus subject areas

  • Gastroenterology

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