Relationship between MRI perfusion and clinical severity in multiple sclerosis

Research output: Contribution to journalReview article

Abstract

Perfusion alterations within several brain regions have been shown in multiple sclerosis patients using different magnetic resonance imaging (MRI) techniques. Furthermore, MRI-derived brain perfusion metrics have been investigated in association with multiple sclerosis phenotypes, physical disability, and cognitive impairment. However, a review focused on these aspects is still missing. Our aim was to review all the studies investigating the relationship between perfusion MRI and clinical severity during the last fifteen years to understand the clinical relevance of these findings. Perfusion differences among phenotypes were observed both with 1.5T and 3T scanners, with progressive multiple sclerosis presenting with lower perfusion values than relapsing-remitting multiple sclerosis patients. However, only 3T scanners showed a statistically significant distinction. Controversial results about the association between MRI-derived perfusion metrics and physical disability scores were found. However, the majority of the studies showed that lower brain perfusion and longer transit time are associated with more severe physical disability and worse cognitive performances.

Original languageEnglish
Pages (from-to)646-652
Number of pages7
JournalNeural Regeneration Research
Volume15
Issue number4
DOIs
Publication statusPublished - Apr 1 2020

Fingerprint

Magnetic Resonance Angiography
Multiple Sclerosis
Perfusion
Brain
Magnetic Resonance Imaging
Phenotype
Relapsing-Remitting Multiple Sclerosis

Keywords

  • brain perfusion
  • cerebral blood flow
  • cognition; disability
  • magnetic resonance imaging
  • MRI
  • multiple sclerosis
  • phenotypes
  • progressive
  • relapsing remitting

ASJC Scopus subject areas

  • Developmental Neuroscience

Cite this

Relationship between MRI perfusion and clinical severity in multiple sclerosis. / Lagana, Maria; Pelizzari, Laura; Baglio, Francesca.

In: Neural Regeneration Research, Vol. 15, No. 4, 01.04.2020, p. 646-652.

Research output: Contribution to journalReview article

@article{4f4ff43dbbbc4c3ba925ea90ec4bd587,
title = "Relationship between MRI perfusion and clinical severity in multiple sclerosis",
abstract = "Perfusion alterations within several brain regions have been shown in multiple sclerosis patients using different magnetic resonance imaging (MRI) techniques. Furthermore, MRI-derived brain perfusion metrics have been investigated in association with multiple sclerosis phenotypes, physical disability, and cognitive impairment. However, a review focused on these aspects is still missing. Our aim was to review all the studies investigating the relationship between perfusion MRI and clinical severity during the last fifteen years to understand the clinical relevance of these findings. Perfusion differences among phenotypes were observed both with 1.5T and 3T scanners, with progressive multiple sclerosis presenting with lower perfusion values than relapsing-remitting multiple sclerosis patients. However, only 3T scanners showed a statistically significant distinction. Controversial results about the association between MRI-derived perfusion metrics and physical disability scores were found. However, the majority of the studies showed that lower brain perfusion and longer transit time are associated with more severe physical disability and worse cognitive performances.",
keywords = "brain perfusion, cerebral blood flow, cognition; disability, magnetic resonance imaging, MRI, multiple sclerosis, phenotypes, progressive, relapsing remitting",
author = "Maria Lagana and Laura Pelizzari and Francesca Baglio",
year = "2020",
month = "4",
day = "1",
doi = "10.4103/1673-5374.266906",
language = "English",
volume = "15",
pages = "646--652",
journal = "Neural Regeneration Research",
issn = "1673-5374",
publisher = "Editorial Board of Neural Regeneration Research",
number = "4",

}

TY - JOUR

T1 - Relationship between MRI perfusion and clinical severity in multiple sclerosis

AU - Lagana, Maria

AU - Pelizzari, Laura

AU - Baglio, Francesca

PY - 2020/4/1

Y1 - 2020/4/1

N2 - Perfusion alterations within several brain regions have been shown in multiple sclerosis patients using different magnetic resonance imaging (MRI) techniques. Furthermore, MRI-derived brain perfusion metrics have been investigated in association with multiple sclerosis phenotypes, physical disability, and cognitive impairment. However, a review focused on these aspects is still missing. Our aim was to review all the studies investigating the relationship between perfusion MRI and clinical severity during the last fifteen years to understand the clinical relevance of these findings. Perfusion differences among phenotypes were observed both with 1.5T and 3T scanners, with progressive multiple sclerosis presenting with lower perfusion values than relapsing-remitting multiple sclerosis patients. However, only 3T scanners showed a statistically significant distinction. Controversial results about the association between MRI-derived perfusion metrics and physical disability scores were found. However, the majority of the studies showed that lower brain perfusion and longer transit time are associated with more severe physical disability and worse cognitive performances.

AB - Perfusion alterations within several brain regions have been shown in multiple sclerosis patients using different magnetic resonance imaging (MRI) techniques. Furthermore, MRI-derived brain perfusion metrics have been investigated in association with multiple sclerosis phenotypes, physical disability, and cognitive impairment. However, a review focused on these aspects is still missing. Our aim was to review all the studies investigating the relationship between perfusion MRI and clinical severity during the last fifteen years to understand the clinical relevance of these findings. Perfusion differences among phenotypes were observed both with 1.5T and 3T scanners, with progressive multiple sclerosis presenting with lower perfusion values than relapsing-remitting multiple sclerosis patients. However, only 3T scanners showed a statistically significant distinction. Controversial results about the association between MRI-derived perfusion metrics and physical disability scores were found. However, the majority of the studies showed that lower brain perfusion and longer transit time are associated with more severe physical disability and worse cognitive performances.

KW - brain perfusion

KW - cerebral blood flow

KW - cognition; disability

KW - magnetic resonance imaging

KW - MRI

KW - multiple sclerosis

KW - phenotypes

KW - progressive

KW - relapsing remitting

UR - http://www.scopus.com/inward/record.url?scp=85073771343&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85073771343&partnerID=8YFLogxK

U2 - 10.4103/1673-5374.266906

DO - 10.4103/1673-5374.266906

M3 - Review article

AN - SCOPUS:85073771343

VL - 15

SP - 646

EP - 652

JO - Neural Regeneration Research

JF - Neural Regeneration Research

SN - 1673-5374

IS - 4

ER -