Relationship between MRI perfusion and clinical severity in multiple sclerosis

Research output: Contribution to journalReview articlepeer-review


Perfusion alterations within several brain regions have been shown in multiple sclerosis patients using different magnetic resonance imaging (MRI) techniques. Furthermore, MRI-derived brain perfusion metrics have been investigated in association with multiple sclerosis phenotypes, physical disability, and cognitive impairment. However, a review focused on these aspects is still missing. Our aim was to review all the studies investigating the relationship between perfusion MRI and clinical severity during the last fifteen years to understand the clinical relevance of these findings. Perfusion differences among phenotypes were observed both with 1.5T and 3T scanners, with progressive multiple sclerosis presenting with lower perfusion values than relapsing-remitting multiple sclerosis patients. However, only 3T scanners showed a statistically significant distinction. Controversial results about the association between MRI-derived perfusion metrics and physical disability scores were found. However, the majority of the studies showed that lower brain perfusion and longer transit time are associated with more severe physical disability and worse cognitive performances.

Original languageEnglish
Pages (from-to)646-652
Number of pages7
JournalNeural Regeneration Research
Issue number4
Early online dateOct 8 2019
Publication statusPublished - Apr 1 2020


  • brain perfusion
  • cerebral blood flow
  • cognition; disability
  • magnetic resonance imaging
  • MRI
  • multiple sclerosis
  • phenotypes
  • progressive
  • relapsing remitting

ASJC Scopus subject areas

  • Developmental Neuroscience


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