Relationship between non-fibrillary amyloid precursors and cell processes in the cortical neuropil of Alzheimer patients

Khalid Hamid El Hachimi, Laura Verga, Giorgio Giaccone, Fabrizio Tagliavini, Blas Frangione, Orso Bugiani, Jean François Foncin

Research output: Contribution to journalArticle

Abstract

We examined the ultrastructural localization of amyloid β-protein in 8 Alzheimer neocortical biopsies. Intense immunoreactivity was located extracellularly on amyloid fibrils and amorphous material. Amorphous labelled material was also found in cell processes. No ultrastructural cell marker, such as glial fibrils, glycogen, tubules, paired helical filaments (PFHs) or synaptic vesicles could be seen in these processes that could allow their identification as glial processes, neurites or presynaptic terminals, respectively; occasional membrane stacks were observed. These findings suggest that preamyloid deposits are related to cell processes and, by elimination, that postsynaptic terminals may be involved in abnormal metabolism of the amyloid fibril precursors.

Original languageEnglish
Pages (from-to)119-122
Number of pages4
JournalNeuroscience Letters
Volume129
Issue number1
DOIs
Publication statusPublished - Aug 5 1991

Keywords

  • Alzheimer's disease
  • Amyloid
  • Golgi
  • Immunoelectronmicroscopy
  • Postsynaptic element
  • Preamyloid deposit

ASJC Scopus subject areas

  • Neuroscience(all)

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