Relationship between P-glycoprotein expression and p53 status in high-grade osteosarcoma

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

The transcription of MDR1 gene may be increased by mutation or loss of function of p53 gene. In this study, we investigated whether in osteosarcoma, the p53 status is correlated with overexpression of the MDR1 gene product P-glycoprotein. The relationship between P-glycoprotein expression and p53 status was analyzed by immunohistochemistry in 64 primary and 11 metastatic high-grade osteosarcomas. In the same series, we also assessed the nuclear accumulation of MDM2 protein, whose binding to p53 protein provides an alternative mechanism of p53 inactivation. No association was found between mutant-p53 and MDM2 nuclear accumulation either with P-glycoprotein expression or with clinical course. Only increased expression of P-glycoprotein in tumor cells was significantly associated with a poor outcome, further supporting the adverse prognostic value of this marker in osteosarcoma.

Original languageEnglish
Pages (from-to)301-307
Number of pages7
JournalInternational Journal of Oncology
Volume14
Issue number2
Publication statusPublished - 1999

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P-Glycoprotein
Osteosarcoma
p53 Genes
Protein Binding
Genes
Immunohistochemistry
Mutation
Neoplasms
Proteins

Keywords

  • MDM2
  • Multidrug resistance
  • Osteosarcoma
  • P-glycoprotein
  • p53

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Relationship between P-glycoprotein expression and p53 status in high-grade osteosarcoma. / Serra, Massimo.

In: International Journal of Oncology, Vol. 14, No. 2, 1999, p. 301-307.

Research output: Contribution to journalArticle

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