Relationship between plasma and hepatic cytosolic levels of ornithine decarboxylase (ODC) and thymidine kinase (TK) in 70% hepatectomized rats

Lorenzo Polimeno, Alessandro Azzarone, Paola Dell'Aquila, Cinzia Amoruso, Michele Barone, Annamaria Angelini, David H. Van Thiel, Antonio Francavilla

Research output: Contribution to journalArticle

Abstract

Ornithine decarboxylase (ODC) and thymidine kinase (TK) are enzymes important for DNA synthesis, a process that is critical for cell renewal and regeneration. As such, they already have been used as surrogate markers of regeneration in tissue. In the present study, the activity of these two enzymes in plasma of rats and regenerating hepatic tissue following a 70% hepatectomy were determined. The results demonstrate that the changes in these enzyme activities in plasma reflect the changes obtained in the liver tissue. Thus, blood levels of ODC and TK can be used as a less invasive and nondestructive means of monitoring the regenerative response of the liver and possibly other tissues.

Original languageEnglish
Pages (from-to)289-292
Number of pages4
JournalDigestive Diseases and Sciences
Volume36
Issue number3
DOIs
Publication statusPublished - Mar 1991

Keywords

  • liver regeneration
  • ODC
  • TK

ASJC Scopus subject areas

  • Gastroenterology

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    Polimeno, L., Azzarone, A., Dell'Aquila, P., Amoruso, C., Barone, M., Angelini, A., Van Thiel, D. H., & Francavilla, A. (1991). Relationship between plasma and hepatic cytosolic levels of ornithine decarboxylase (ODC) and thymidine kinase (TK) in 70% hepatectomized rats. Digestive Diseases and Sciences, 36(3), 289-292. https://doi.org/10.1007/BF01318198