Relationship between plasma atrial natriuretic factor and urinary kallikrein excretion in essential hypertensives

P. Dessi-Fulgheri, G. Di Noto, R. Palermo, R. Catalini, P. Russo, A. Rappelli

Research output: Contribution to journalArticle

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Abstract

In order to seek possible relationships between renal kallikrein and atrial natriuretic factor (ANF), we measured urinary kallikrein (UK) and ANF in 84 normal subjects (NS) and in 104 uncomplicated essential hypertensives (HP). Atrial natriuretic factor was significantly higher in HP than in NS (38.5 ± 1.3 v 29.0 ± 1.3 pg/mL, P <.01), whereas UK was significantly lower in HP than in NS (11.1 ± 0.9 v 15.3 ± 0.6 nkatal/24 h, P <.01). Calculating the 95% of the percentile distribution of the single values of UK in the group of NS we were able to show that 24 out of 104 HP had a UK which fell below the lowest limit (4.5 nkat/24 h) of the normal range. We therefore divided our HP into two subgroups: patients with normal kallikrein excretion (NK) (n = 80; mean UK 13.8 ± 0.8 nkat/24 h) and patients with low kallikrein excretion (LK) (n = 24; mean UK 2.3 ± 0.3 nkat/24 h). Normal kallikrein patients had a mean plasma ANF value of 31.9 ± 1.2 pg/mL which was almost superimposable to that found in NS; on the contrary, the mean plasma level of ANF in LK patients (50.7 ± 2.2 pg/mL) was significantly higher than that measured in NK patients and in NS (P <.01 v NK patients and NS, respectively). Since a low urinary kallikrein excretion may represent a marker of an impaired production of renal kallikrein, the high levels of ANF found the in LK subgroup could be the result of a compensatory response of the atrium attempting to maintain sodium and volume homeostasis.

Original languageEnglish
Pages (from-to)214-218
Number of pages5
JournalAmerican Journal of Hypertension
Volume4
Issue number3 I
Publication statusPublished - 1991

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Tissue Kallikreins
Kallikreins
Atrial Natriuretic Factor
Kidney
Reference Values
Homeostasis
Sodium

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Dessi-Fulgheri, P., Di Noto, G., Palermo, R., Catalini, R., Russo, P., & Rappelli, A. (1991). Relationship between plasma atrial natriuretic factor and urinary kallikrein excretion in essential hypertensives. American Journal of Hypertension, 4(3 I), 214-218.

Relationship between plasma atrial natriuretic factor and urinary kallikrein excretion in essential hypertensives. / Dessi-Fulgheri, P.; Di Noto, G.; Palermo, R.; Catalini, R.; Russo, P.; Rappelli, A.

In: American Journal of Hypertension, Vol. 4, No. 3 I, 1991, p. 214-218.

Research output: Contribution to journalArticle

Dessi-Fulgheri, P, Di Noto, G, Palermo, R, Catalini, R, Russo, P & Rappelli, A 1991, 'Relationship between plasma atrial natriuretic factor and urinary kallikrein excretion in essential hypertensives', American Journal of Hypertension, vol. 4, no. 3 I, pp. 214-218.
Dessi-Fulgheri P, Di Noto G, Palermo R, Catalini R, Russo P, Rappelli A. Relationship between plasma atrial natriuretic factor and urinary kallikrein excretion in essential hypertensives. American Journal of Hypertension. 1991;4(3 I):214-218.
Dessi-Fulgheri, P. ; Di Noto, G. ; Palermo, R. ; Catalini, R. ; Russo, P. ; Rappelli, A. / Relationship between plasma atrial natriuretic factor and urinary kallikrein excretion in essential hypertensives. In: American Journal of Hypertension. 1991 ; Vol. 4, No. 3 I. pp. 214-218.
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abstract = "In order to seek possible relationships between renal kallikrein and atrial natriuretic factor (ANF), we measured urinary kallikrein (UK) and ANF in 84 normal subjects (NS) and in 104 uncomplicated essential hypertensives (HP). Atrial natriuretic factor was significantly higher in HP than in NS (38.5 ± 1.3 v 29.0 ± 1.3 pg/mL, P <.01), whereas UK was significantly lower in HP than in NS (11.1 ± 0.9 v 15.3 ± 0.6 nkatal/24 h, P <.01). Calculating the 95{\%} of the percentile distribution of the single values of UK in the group of NS we were able to show that 24 out of 104 HP had a UK which fell below the lowest limit (4.5 nkat/24 h) of the normal range. We therefore divided our HP into two subgroups: patients with normal kallikrein excretion (NK) (n = 80; mean UK 13.8 ± 0.8 nkat/24 h) and patients with low kallikrein excretion (LK) (n = 24; mean UK 2.3 ± 0.3 nkat/24 h). Normal kallikrein patients had a mean plasma ANF value of 31.9 ± 1.2 pg/mL which was almost superimposable to that found in NS; on the contrary, the mean plasma level of ANF in LK patients (50.7 ± 2.2 pg/mL) was significantly higher than that measured in NK patients and in NS (P <.01 v NK patients and NS, respectively). Since a low urinary kallikrein excretion may represent a marker of an impaired production of renal kallikrein, the high levels of ANF found the in LK subgroup could be the result of a compensatory response of the atrium attempting to maintain sodium and volume homeostasis.",
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