Correlazione tra presenza ed estensione delle placche pleuriche e indicatori biologici di esposizione ad asbesto. Uno studio autoptico

Translated title of the contribution: Relationship between pleural plaques prevalence and extension and biomarkers of cumulative asbestos dose. A necropsy study

Pietro Gino Barbieri, Dario Consonni, Anna Somigliana

Research output: Contribution to journalArticle

Abstract

Background: The relationship between pleural plaques and cumulative asbestos exposure is controversial. Objectives: To evaluate the relationship between lung asbestos bodies (AB) and fibres (AF) and plaques presence and extension. Methods: In a necropsy series of shipyard workers with asbestos-related diseases, we measured counts (per g of dry lung tissue) of AB (thousands) and AF>1 μm (millions). Pleural plaques were classified into three extension grades. We fitted univariate and multivariable linear (dependent variables: AB and AF, log10 transformed) and multinomial (dependent variable: plaques grade) regression models. Results: We analysed 124 subjects, 13 without plaques 20 with grade 1, 69 with grade 2, and 22 with grade 3 plaques. Geometric means (GM) of AB were 10.6, 23.3, 126, and 140 in the four groups respectively (P=0.0001). GMs for AF (mostly amphiboles) were 1.2, 1.4, 7.3, and 12.9 (P=0.0001). AB and AF were strongly correlated (r=0.81). The likelihood of no plaques and grade 1 plaques decreased with increasing AB and AF doses, with a corresponding increase of grade 2 and 3 plaques. Plaque presence and extension was also associated with histologically verified asbestosis (P<0.001). Conclusions: Our study showed a strong positive relationship between pleural plaque presence and extension and both lung asbestos burden and asbestosis.

Translated title of the contributionRelationship between pleural plaques prevalence and extension and biomarkers of cumulative asbestos dose. A necropsy study
Original languageItalian
Pages (from-to)353-362
Number of pages10
JournalMedicina del Lavoro
Volume110
Issue number5
DOIs
Publication statusPublished - Sep 1 2019

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Fingerprint Dive into the research topics of 'Relationship between pleural plaques prevalence and extension and biomarkers of cumulative asbestos dose. A necropsy study'. Together they form a unique fingerprint.

  • Cite this