Relationship between quality of life and behavioural disorders in children with persistent asthma: a Multiple Indicators Multiple Causes (MIMIC) model: Scientific Reports

L. Montalbano, G. Ferrante, S. Montella, G. Cilluffo, A. Di Marco, S. Bozzetto, E. Di Palmo, A. Licari, L. Leonardi, V. Caldarelli, M. Ghezzi, S. La Grutta, F. Rusconi, S. Amarri, S. Barni, A. Capizzi, F. Cardinale, S. Carraro, S. Cazzato, R. CutreraS. Di Pillo, M. Duse, G. Fenu, A. Kantar, S. Leonardi, E. Lombardi, G.L. Marseglia, L. Nosetti, E. Novembre, M.F. Patria, G. Piacentini, G. Pisi, G. Ricci, O. Sacco, F. Santamaria, L. Tenero, M.A. Tosca, M.C. Tripodi, A. Volpini, the Italian Pediatric Severe Asthma Network (IPSAN) Program of Italian Paediatric Respiratory Society (IPRS)

Research output: Contribution to journalArticlepeer-review

Abstract

Knowledge on multiple interdependences between quality of life (QoL) and behavioural problems in relation to asthma severity and control is undetermined. The aims of the study were: (i) to assess the relationship of QoL and behavioural problems with asthma severity and control (ii) to predict children’s “abnormal/borderline” status with variation in QoL. For these purposes a multicenter case-control study on 47 Severe Asthma (SA) and 94 Moderate Asthma (MA) children was performed. The MIMIC approach was applied to investigate the effect of SA and non-controlled asthma (NC) on QoL and behavioural disorders. Logistic regression was used to estimate probabilities of having an “abnormal/borderline” status with variation in QoL. The MIMIC model showed that the magnitude of the effect of SA and NC was larger on QoL (β = −0.37 and β = −0.30, respectively) than on behavioural problems (β = 0.27). With regards to the probability of having a borderline status, in MA a QoL of 1 returned a probability of 0.81, whereas in SA a QoL of 1 returned a probability of 0.89. In conclusion, SA children are highly affected by impaired QoL and behavioural problems. The MIMIC model allowed us to obtain a comprehensive assessment of QoL and behavioural problems with asthma severity and control. © 2020, The Author(s).
Original languageEnglish
JournalSci. Rep.
Volume10
Issue number1
DOIs
Publication statusPublished - 2020

Keywords

  • asthma
  • case control study
  • child
  • female
  • human
  • male
  • pathophysiology
  • problem behavior
  • psychology
  • quality of life
  • statistical model
  • Asthma
  • Case-Control Studies
  • Child
  • Female
  • Humans
  • Logistic Models
  • Male
  • Problem Behavior
  • Quality of Life

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