Relationship between retinal ischemia and cardiovascular autonomic damage in diabetes

Angela Giardullo, Luigi Ricordi, Marco Rossi, Giuliano Marti, Giulio Vandelli, Pietro Fratino, Luciano Bernardi

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

In order to investigate the relationship between ischemic diabetic retinopathy and cardiac autonomic dysfunction we studied 40 diabetic patients (mean age ± SEM: 48 ± 2 years). Retinopathy was evaluated by fluorescein angiography and patients were divided into three groups: a) with ischemic retinopathy (15 patients), b) with edematous retinopathy (13 patients) and c) without retinopathy (12 patients). Cardiac autonomic function was assessed by 4 tests based on cardiovascular reflexes (heart rate response to Valsalva maneuver and to deep breathing; systolic blood pressure fall after standing and diastolic blood pressure rise during handgrip) and by the cross-correlation test, a computerized technique for the analysis of respiratory sinus arrhythmia based on spectral analysis of electrocardiographic and respiratory signals. Abnormalities of cardiac autonomic tests were present in 26/40 patients (65%); considering the retinal angiographic classification, autonomic test abnormalities were found in 13/15 (86.6%) patients with ischemic retinopathy, in 7/13 (53.9%) patients with edematous retinopathy and in 6/12 (50%) patients without retinopathy. The prevalence of cardiac autonomic dysfunction was significantly higher (p

Original languageEnglish
Pages (from-to)245-255
Number of pages11
JournalActa Diabetologica Latina
Volume26
Issue number3
DOIs
Publication statusPublished - Sep 1989

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Ischemia
Blood Pressure
Valsalva Maneuver
Fluorescein Angiography
Diabetic Retinopathy
Reflex
Respiration
Heart Rate

Keywords

  • Autonomic neuropathy
  • Diabetic retinopathy
  • Fluorescein angiography
  • Spectral analysis

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Giardullo, A., Ricordi, L., Rossi, M., Marti, G., Vandelli, G., Fratino, P., & Bernardi, L. (1989). Relationship between retinal ischemia and cardiovascular autonomic damage in diabetes. Acta Diabetologica Latina, 26(3), 245-255. https://doi.org/10.1007/BF02581391

Relationship between retinal ischemia and cardiovascular autonomic damage in diabetes. / Giardullo, Angela; Ricordi, Luigi; Rossi, Marco; Marti, Giuliano; Vandelli, Giulio; Fratino, Pietro; Bernardi, Luciano.

In: Acta Diabetologica Latina, Vol. 26, No. 3, 09.1989, p. 245-255.

Research output: Contribution to journalArticle

Giardullo, A, Ricordi, L, Rossi, M, Marti, G, Vandelli, G, Fratino, P & Bernardi, L 1989, 'Relationship between retinal ischemia and cardiovascular autonomic damage in diabetes', Acta Diabetologica Latina, vol. 26, no. 3, pp. 245-255. https://doi.org/10.1007/BF02581391
Giardullo, Angela ; Ricordi, Luigi ; Rossi, Marco ; Marti, Giuliano ; Vandelli, Giulio ; Fratino, Pietro ; Bernardi, Luciano. / Relationship between retinal ischemia and cardiovascular autonomic damage in diabetes. In: Acta Diabetologica Latina. 1989 ; Vol. 26, No. 3. pp. 245-255.
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